Cannabidiolic acid (cbda) synthase variants, and manufacture and use thereof

ABSTRACT

Provided herein is a recombinant vector that comprises a promoter, a secretion tag gene of interest (GOI), and optionally a purification and/or a detection tag. The GOI comprises a polynucleotide sequence of SEQ ID NOs: 2-45 or a polynucleotide sequence with at least 90%, 95%, 98%, 99% or 99.9% identity with any one of SEQ ID NOs: 2-45. Also, disclosed are the sequences of polypeptides that result from expression of a GOI by a host expression system, and a method of producing cannabinoid compounds.

CROSS-REFERENCE TO RELATED APPLICATIONS

The present application claims priority under 35 U.S.C. § 119(e) to U.S.Provisional Patent Application 63/113,274, filed Nov. 13, 2020, which isherein incorporated by reference in its entirety.

BACKGROUND

Cannabinoids, the terpenophenolic compounds found in Cannabis sativa,have proven therapeutic potential. For example, cannabidiol (CBD) is apotent antioxidant and anti-inflammatory compound and may provideprotection against acute and chronic neurodegeneration. It is found inhigh concentrations in hemp and acts as a high-affinity α2-adrenergicreceptor agonist, a moderate-affinity 5-HT1A receptor antagonist, and alow-affinity CB1 receptor antagonist. CBD may also have anti-depressantactivity. Cannabichromene (CBC) possesses anti-inflammatory,anti-fungal, and anti-viral properties. Thus, cannabinoids are regardedas promising therapeutic agents for the treatment of various diseases.

The varins are a class of cannabinoids that are structurally differentfrom the classical cannabinoids (e.g., Tetrahydrocannabinol (THC), CBD,Cannabigerol (CBG), or CBC and their corresponding carboxylic acids).The varins have a 3-carbon propyl side chain instead of a pentyl(5-carbon) side chain attached to the aromatic ring. Many of the varinsare found in very low amounts in the Cannabis plant.Tetrahydrocannabivarin (THCV) is one widely studied cannabinoid varincompounds. THCV can function as an antagonist of THC at CB1 receptorsand thus attenuate the psychoactive effects of THC. THCV is beingevaluated as a potential therapeutic for the treatment for type 2diabetes, by increasing insulin sensitivity and improving glucosetolerance in patients with type-2 diabetes (Wargent et al., NutrDiabetes., May; 3(5): e68 (2013)). THCV has also shown promise for thetreatment of epilepsy and in reducing tremors associated withParkinson's disease. Another minor cannabinoid is cannabidivarin (CBDV),an analog of cannabidiol. CBDV is presently being tested as atherapeutic for the treatment of adult epilepsy.

However, traditional chemical synthesis of many cannabinoids,particularly the low abundance varins is either suboptimal,non-existing, and/or does not permit the cost-effective manufacture ofcannabinoids in high yields and at commercial scales. Thus, there is aneed to develop a more effective system for industrial-scale manufactureof cannabinoid compounds. Bio-catalysis provides one cost-effectivemethod for producing many cannabinoids found in the Cannabis plant. Theprocess requires contacting a cannabinoid synthase enzyme with asubstrate of the enzyme to produce cannabinoids and the low abundancevarins at commercial scale and in pharmaceutical grade purity. Whileexisting protocols, such as the one described in U.S. Pat. No.10,336,978 is focused on using cannabinoid synthase enzymes, namely,CBDA synthase and THCA synthase found in the Cannabis plant, for thebio-catalytic manufacture of cannabinoids, the focus of this applicationis on mutants of CBDA synthase that have improved yields and enhancedkinetic rates compared to the plant (botanical) CBDA synthase enzyme.

SUMMARY OF THE INVENTION

In one aspect, the present invention provides a recombinant vector thatcomprises a promoter, secretion tag, gene of interest (GOI), andoptionally a purification and/or a detection tag, wherein the gene ofinterest comprises a polynucleotide sequence encoding a polypeptide withat least 90%, 95%, 98%, or 99.9% sequence identity to the sequence asset forth in any one of SEQ ID NOs: 72-115.

In another aspect, the present invention provides a polynucleotidecomprising a polynucleotide sequence as set forth in any one of SEQ IDNo. 2-45, or a polynucleotide sequence comprising at least 90%, 95%,98%, 99%, or 99.9%, sequence identity to a sequence as set forth in anyone of SEQ ID NOs: 2-45.

In some aspects, the present invention provides a polypeptide comprisingthe amino acid sequence of any one of SEQ ID NOs: 72-115 or apolypeptide comprising an amino acid sequence having at least 90%, 95%,98%, or 99.9% sequence identity to a sequence as set forth in any one ofSEQ ID NOs: 72-115.

In other aspects, the present invention provides a gene of interestoperably linked to a promoter which is a polynucleotide as set forth inany one of SEQ ID NOs: 59-68. In one aspect, the present inventionprovides a promoter having a polynucleotide sequence comprising at least90%, 95%, 98%, or 99% sequence identity to the sequence of SEQ ID NOs:59-68.

In another aspect, the present invention provides a promoter that is aconstitutive promoter or an inducible promoter. In one embodiment, thepromoter is selected from a group consisting of an alcohol oxidase 1promoter (pAOX1), an alcohol oxidase 2 promoter (pAOX2), adihydroxyacetone kinase promoter (pDAK), an S-hydroxymethyl-glutathionehydrolase promoter (pFGH), an NADY-dependent formylglutathionedehydrogenase promoter (pFDH), a fructose 1,6-bisphosphate aldolasepromoter (pFBA2), a peroxisomal membrane signal receptor PTS1 promoter(pPEX5), a peroxisomal protein Pex8p promoter (pPEX8), an alcoholdehydrogenase 2 promoter (pADH2) and a peroxin Pex14p promoter (pPEX14).

In some aspects, the present invention provides a recombinant vectorcomprising a secretion tag as set forth in any one of SEQ ID NOs: 46-55and 130 or a secretion tag whose sequence is at least 90%, 95%, 98%,99%, 99.9%, or 100% identical to SEQ ID NOs: 46-55 and 130.

In other aspects, the present invention provides a recombinant vectorcomprising a purification and/or a detection tag as set forth in any oneof SEQ ID NOs: 56-58 and 129. In one embodiment, the purification tag isselected from the group consisting of a human influenza hemagglutinin(HA) tag, a His 6 tag and an HN tag.

In one aspect, the present invention provides a host expression systemcomprising a recombinant vector that comprises a promoter, secretiontag, gene of interest (GOI), and optionally a purification and/or adetection tag.

In another aspect, the present invention provides a host expressionsystem comprising a microbial cell, a yeast cell, a plant cell, or ananimal cell.

In some aspects, the present invention provides a host expression systemcomprising a yeast cell is selected from the group consisting of Pichiapastoris, Pichia angusta, Pichia guillermordii, Pichia methanolica,Pichia inositovera, Hansenula polymorpha, Candida boidinii, and Yarrowialipolytica.

In other aspects, the present invention provides a method of producing aCannabidiolic acid (CBDA) synthase or its variants. In anotherembodiment, the invention provides a method for producing a cannabinoidby contacting a cannabinoid precursor with an enzyme that is expressedby the recombinant vector of this disclosure.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the expression cassette for a recombinant vector accordingto one embodiment of the invention.

FIG. 2 shows the high-pressure liquid chromatography (HPLC) plot ofenzyme assay sample of CBDA synthase of SEQ ID NO: 71.

FIG. 3 shows the HPLC plot of enzyme assay sample of CBDA synthase ofSEQ ID NO: 75.

FIG. 4 shows the HPLC plot of enzyme assay sample of CBDA synthase ofSEQ ID NO: 77.

DETAILED DESCRIPTION

It is to be understood that the invention is not limited to particularmethodologies, protocols, cell lines, animal species or genera,compounds, polymers, and reagents described, as such may vary. It isalso to be understood that the terminology used herein is for thepurpose of describing particular embodiments only and is not intended tolimit the scope of the present invention, which will be limited only bythe appended claims.

Terms as set forth hereinafter are generally to be understood in theircommon sense unless indicated otherwise.

Unless otherwise defined, scientific and technical terms used hereinhave the meanings that are commonly understood by those of ordinaryskill in the art. In the event of any latent ambiguity, definitionsprovided herein take precedent over any dictionary or extrinsicdefinition. Unless otherwise required by context, singular terms shallinclude pluralities and plural terms shall include the singular. The useof “or” means “and/or” unless stated otherwise. The use of the term“including,” as well as other forms, such as “includes” and “included,”is not limiting.

That the disclosure may be more readily understood, select terms aredefined below.

The articles “a” and “an” are used herein to refer to one or to morethan one (i.e., to at least one) of the grammatical object of thearticle. By way of example, “an element” means one element or more thanone element.

“About” as used herein when referring to a measurable value such as anamount, a temporal duration, and the like, is meant to encompassvariations of 20% or ±10%, more preferably ±5%, even more preferably+1%, and still more preferably +0.1% from the specified value, as suchvariations are appropriate to perform the disclosed methods.

The term “comprising” or “comprises” is intended to mean that thecompositions and methods include the recited elements, but do notexclude others. “Consisting essentially of,” when used to definecompositions and methods, shall mean excluding other elements of anyessential significance to the combination. For example, a compositionconsisting essentially of the elements as defined herein would notexclude other elements that do not materially affect the basic and novelcharacteristic(s) of the claimed invention. “Consisting of” shall meanexcluding more than a trace amount of other ingredients and substantialmethod steps recited. Embodiments defined by each of these transitionterms are within the scope of this invention.

The term “isolated” means altered or removed from the natural state. Forexample, a nucleic acid or a peptide naturally present in a livinganimal is not “isolated,” but the same nucleic acid or peptide partiallyor completely separated from the coexisting materials of its naturalstate is “isolated.” An isolated nucleic acid or protein can exist insubstantially purified form, or can exist in a non-native environmentsuch as, for example, a host cell.

As used herein, the term “precursor” refers to a compound thatparticipates in a chemical reaction that produces another compound. Inone embodiment, the cannabinoid precursor refers to a compound thatparticipates in a reaction to produce another compound.

For example, CBGA is a precursor to THCA, CBDA, and CBCA. In anotherexample, CBGVA is a precursor to THCVA, CBDVA, and CBCVA.

The terms “nucleic acid” and “polynucleotide” as used herein areinterchangeable. Nucleic acids and polynucleotides are polymers ofnucleotides.

The nucleic acids of the present disclosure may include naturallyoccurring bases including adenine, guanine, cytosine, thymidine, anduracil. The sequences of nucleic acids may also contain modified bases.Examples of such modified bases include aza- and deaza-adenine, guanine,cytosine, thymidine and uracil; and xanthine and hypoxanthine. In oneembodiment, the polynucleotide or nucleic acid molecule is acomplementary DNA (cDNA).

A polypeptide, in one embodiment, may include various structural formsof the primary protein. For example, a polypeptide of the disclosure maybe in the form of acidic or basic salts or in neutral form. In addition,individual amino acid residues may be modified by oxidation orreduction. The proteins and polypeptides of the present disclosure mayalso include truncations, analogs and homologs of the proteins andpolypeptides, as described herein, having substantially the samefunction as the proteins or polypeptides of the present disclosure, suchas having CBDA synthase activity.

The term “sequence identity” or “identity” refers to the maximumcorrespondence relation of the amino acid or nucleotide residues in thetwo sequences that are aligned for comparison. The length for identitycomparison may extend to the full length of a nucleotide or polypeptidesequence, or a fragment of a nucleotide or polypeptide sequence that isat least about nine residues, at least about 20 to 24 residues, at leastabout 28 to 32 residues, and preferably at least about 36 or greaterthan 36 residues. Several different algorithms known in the art that canbe used to measure sequence identity. In one embodiment, the sequenceidentity is in a range from about 50% to about 99.9%, about 55% to about99.9%, about 60% to about 99.9%, about 65% to about 99.9%, about 70% toabout 99.9%, about 75% to about 99.9%, about 80% to about 99.9%, about85% to about 99.9%, about 90% to about 99.9%, and about 95% to about99.9%.

In one embodiment, the sequence identity between two polynucleotides ortwo polypeptides is about 99.5%, about 98.5%, about 97.5%, about 96.5%,about 95.5%, about 94.5%, about 93.5%, about 92.5%, about 91.5%, about90.5%, about 89.5%, about 88.5%, about 87.5%, about 86.5%, about 85.5%,about 84.5%, about 84.5%, about 83.5%, about 82.5%, about 81.5%, orabout 80.5%.

In one embodiment, the sequence identity between two polynucleotides ortwo polypeptides is about 99%, about 98%, about 97%, about 96%, about95%, about 94%, about 93%, about 92%, about 91%, about 90%, about 89%,about 88%, about 87%, about 86%, about 85%, about 84%, about 83%, about82%, about 81%, or about 80%.

In one embodiment, the sequence identity between two polynucleotides ortwo polypeptides is about 99.9%, about 99.8%, about 99.7%, about 99.6%,about 99.5%, about 99.4%, about 99.3%, about 99.2%, about 99.1%, orabout 99%.

The term “cannabinoid product” or “cannabinoid compound” is intended tomean any simple or complex substance or compound of natural,semi-synthetic, or synthetic origin, which can act on or modulate theactivity of a cannabinoid receptor in a subject. In some embodiments,the cannabinoid product is an agonist of a cannabinoid receptor. In someembodiments, the cannabinoid product is an antagonist of a cannabinoidreceptor. In yet another embodiment, the cannabinoid product is aninverse-agonist or an inverse-antagonist of a cannabinoid receptor. Inone embodiment, the cannabinoid product comprises phytocannabinoids,endogenous cannabinoids (endocannabinoids), bio-synthetic cannabinoids,or synthetic cannabinoids. In one embodiment, the cannabinoid productcomprises a pentyl side chain on the aromatic ring. Certain cannabinoidshave a propyl side chain. In this application, this class ofcannabinoids may be referred to as “varin.”

Ranges: throughout this disclosure, various aspects of the embodimentscan be presented in a range format. It should be understood that thedescription in range format is merely for convenience and brevity andshould not be construed as an inflexible limitation. Accordingly, thedescription of a range should be considered to have specificallydisclosed all the possible subranges as well as individual numericalvalues within that range. For example, description of a range such asfrom 1 to 6 should be considered to have specifically disclosedsubranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4,from 2 to 6, from 3 to 6 etc., as well as individual numbers within thatrange, for example, 1, 2, 2.7, 3, 4, 5, 5.3, and 6. This appliesregardless of the breadth of the range. Unless otherwise explicitlystated to the contrary, a range that is disclosed also includes theendpoints of the range.

The present invention relates to mutants of CBDA synthase as well asrecombinant vectors that comprises a polynucleotide sequences that codefor CBDA synthase mutants. The CBDA synthase mutants of the inventionhave advantages over CBDA synthase found in the cannabis plant. Forinstance, the mutant CBDA synthases described here have better catalyticoutput compared to CBDA synthase in the cannabis plant. In oneembodiment, the catalytic activity of the mutant CBDA synthases are atleast 1-20 fold greater, at least 2-fold greater, at least 5-foldgreater, at least 10-fold greater, at least 20-fold greater than thecatalytic activity of the native CBDA synthase from the cannabis plant.

In some embodiments, for certain mutants, the catalytic activity is 1-20fold greater than the catalytic activity of CBDA synthase enzyme fromthe cannabis plant. In one embodiment, the catalytic activity is 2-5fold greater than the catalytic activity of CBDA synthase enzyme fromthe cannabis plant. In one embodiment, the catalytic activity of themutants is 5-10 fold greater, or 16- or 20-fold greater than thecatalytic activity of CBDA synthase from the cannabis plant.

In other embodiments, for certain mutants, the catalytic activity isabout 1 to about 20 fold greater than the catalytic activity of a CBDAsynthase having the sequence of SEQ ID NO: 71 or CBDA synthase of thecannabis plant (e.g., native CBDA synthase from a wild-type cannabisplant). In one embodiment, the catalytic activity of the mutant is about2 to about 5 fold greater, about 5 to about 10 fold greater, about 16fold greater, or about 20 fold greater than the catalytic activity of aCBDA synthase having the sequence of SEQ ID NO: 71 or CBDA synthase ofthe cannabis plant (e.g., native CBDA synthase from a wild-type cannabisplant).

Non-limiting cannabinoid products include tetrahydrocannabinol (THC),cannabidiol (CBD), olivetol, cannabinol (CBN), cannabigerol (CBG),cannabichromene (CBC), cannabicyclol (CBCL), nabilone,tetrahydrocannabinolic acid (THCA), cannabichromenic acid (CBCA),cannabicyclol carboxylic acid (CBCLA), cannabigerolic acid (CBGA),cannabidiolic acid (CBDA), cannabinolic acid (CBNA),tetrahydrocannabivarin (THCV), cannabivarin (CBV), cannabidivarin(CBDV), cannabigerovarin (CBGV), cannabichromevarin (CBCV),cannabicyclovarin (CBCLV), cannabicyclovarinic acid (CBCLVA),cannabigerovarinic acid (CBGVA), tetrahydrocannabivarinic acid (THCVA),cannabichrome varinic acid (CBCVA), cannabidivarinic acid (CBDVA), aswell as the prodrugs and pharmaceutically acceptable salts of thesecannabinoids. Exemplary prodrugs include alkyl ethers, haloalkyl ethers,alkyl esters, haloalkyl esters, and aromatic esters, for example CBDdifluoromethyl ether or CBD methyl ether.

As used herein, the term “cannabinoid varin compound” refers tocannabinoid compounds comprising a propyl side chain attached to anaromatic ring. In one embodiment, the cannabinoid varin compound ispsychoactive. In another embodiment, the cannabinoid varin compound isnon-psychoactive. Non-limiting examples of cannabinoid varin compoundsinclude tetrahydrocannabivarin (THCV), cannabivarin (CBV),cannabidivarin (CBDV), cannabigerovarin (CBGV), cannabichromevarin(CBCV), cannabicyclovarin (CBCLV), cannabicyclovarinic acid (CBCLVA),cannabigerovarinic acid (CBGVA), tetrahydrocannabivarinic acid (THCVA),cannabichromevarinic acid (CBCVA), and cannabidivarinic acid (CBDVA), aswell as natural or synthetic molecules that have a basic cannabinoidvarin structure and are modified synthetically to provide a cannabinoidanalog.

The polynucleotide of interest can be cloned into a vector of interestto produce a construct. In an embodiment, the vector is an expressionvector. Examples of expression vectors include but are not limited tocosmids, plasmids, or modified viruses (e.g. replication defectiveretroviruses, adenoviruses, and adeno-associated viruses), so long asthe vector is compatible with the host cell used. The expression vectorsare suitable for transformation of a host cell, which means that theexpression vectors contain a polynucleotide of the application andregulatory sequences selected on the basis of the host cells to be usedfor expression. “Operably linked” is intended to mean that the nucleicacid is linked to regulatory sequences in a manner which allowsexpression of the nucleic acid. In some embodiments, the isolated and/orpurified nucleic acid molecules, polynucleotides or vectors, constructsor in vitro expression systems comprising these isolated and/or purifiednucleic acid molecules, may be used to create transgenic or recombinantorganisms or recombinant cells (e.g. optionally cells of recombinantorganisms) that produce polypeptides with cannabinoid synthase activityand/or modulated levels of polypeptides with cannabinoid synthaseactivity.

In some embodiments, a polynucleotide comprising a sequence encoding apolypeptide described herein, or a vector comprising the polynucleotide,can be codon-optimized e.g., for use in a particular host cell, forexample, a bacterial or plant cell.

FIG. 1 schematically shows an expression cassette used for themanufacture of a CBDA synthase enzyme. In one embodiment, the expressioncassette comprises a gene of interest (GOI) comprising a sequence as setforth in any one of SEQ ID NOs: 2-45 are operably linked to a secretiontag according SEQ ID NOs: 46-55 and 130, which in turn is operablylinked to a promoter sequence as set forth in any one of SEQ ID Nos59-68. The expression cassette is inserted into the yeast genome and isused to express a cannabinoid synthase enzyme. In most cases, apurification/detection tag as set forth in any one of SEQ ID Nos 56-58and 129 is operably linked downstream of the gene of interest to enablepurification and/or detection of the protein expressed by the gene ofinterest.

In one embodiment, the disclosure provides a recombinant vectorcomprising a polynucleotide sequence for the gene of interest (GOI) asset forth in any one of SEQ ID NOs: 2-45, or a recombinant vectorcomprising a polynucleotide sequence with at least 90%, 95%, 98%, or99.9% identity with any one of SEQ ID NOs: 2-45.

In one embodiment, a polynucleotide comprising the polynucleotidesequence as set forth in any one of SEQ ID NOs: 2-45 encodes apolypeptide of SEQ ID NOs: 72-115. In one embodiment, the polynucleotidesequence encodes a polypeptide with at least 90%, 95%, 98%, or 99.9%identity with any one of SEQ ID NOs: 72-115.

In one embodiment, the polynucleotide sequence is operably linked to aregulatory sequence for the transcription and translation of the gene ofinterest (GOI). Suitable regulatory sequences may be derived from avariety of sources, including bacterial, fungal, viral, mammalian, orinsect genes (for example, see the regulatory sequences described inGoeddel, Gene Expression Technology: Methods in Enzymology 185, AcademicPress, San Diego, CA (1990), incorporated herein by reference in itsentirety). Selection of appropriate regulatory sequences is dependent onthe host cell chosen, as discussed below, and may be readilyaccomplished by one of ordinary skill in the art. Examples of suchregulatory sequences include: a transcriptional promoter and enhancer orRNA polymerase binding sequence, a ribosomal binding sequence, includinga translation initiation signal. Additionally, depending on the hostcell chosen and the vector employed, other sequences, such as an originof replication, additional DNA restriction sites, enhancers, andsequences conferring inducibility of transcription may be incorporatedinto the expression vector.

In one embodiment, the regulatory sequence is a promoter. The promoteris functional in the host cell or host expression system. In anotherembodiment, the promoter is a constitutive promoter or an induciblepromoter. In one embodiment, the promoter is selected from a groupconsisting of an alcohol oxidase 1 promoter (pAOX1), an alcohol oxidase2 promoter (pAOX2), a dihydroxyacetone kinase promoter (pDAK), anS-hydroxymethyl-glutathione hydrolase promoter (pFGH), a NAD⁺-dependentformylglutathione dehydrogenase promoter (pFDH), a peroxin Pex14ppromoter (pPEX14p), a fructose 1,6-bisphosphate aldolase promoter(pFBA), a peroxisomal membrane signal receptor PTS1 promoter (pPEX5), analcohol dehydrogenase 2 promoter (pADH2), and a peroxisomal proteinPex8p promoter (pPEX8).

In one embodiment, the promoter is a polynucleotide of SEQ ID NOs: 59-68or a polynucleotide that has at least 90%, 95%, 98%, or 99% identitywith any one of SEQ ID NOs: 59-68.

For some embodiments, the promoter is a polynucleotide that has at least99% identity to a polynucleotide as set forth in any one of SEQ ID NOs:59-68.

According to one embodiment, the promoter is a polynucleotide that hasat least 98% identity to a polynucleotide as set forth in any one of SEQID NOs: 59-68.

In one embodiment, the promoter is a polynucleotide that has at least97% identity to a polynucleotide as set forth in any one of SEQ ID NOs:59-68.

In one embodiment, the promoter is a polynucleotide that has at least96% identity to a polynucleotide as set forth in any one of SEQ ID NOs:59-68.

In one embodiment, the promoter is a polynucleotide that has at least95% identity to a polynucleotide as set forth in any one of SEQ ID NOs:59-68.

In one embodiment, the promoter is a polynucleotide that has at least90%, 91%, 92%, 93%, 94%, or 95% identity to a polynucleotide as setforth in any one of SEQ ID NOs: 59-68.

In one embodiment, the promoter is a polynucleotide sequence selectedfrom a group consisting of SEQ ID NOs: 59-68.

In one embodiment, the vector encodes a polynucleotide for a secretionpeptide. In one embodiment, the secretion peptide is encoded by apolynucleotide sequence of SEQ ID NOs: 46-55 and 130 or having at least90%, 95%, 98%, 99%, or 100% identity with a polynucleotide of one of SEQID NOs: 46-55 and 130.

In one embodiment, the secretion peptide is encoded by a polynucleotidesequence having at least 99% identity with any one of SEQ ID NOs: 46-55and 130.

In one embodiment, the secretion peptide is encoded by a polynucleotidesequence having at least 98% identity with any one of SEQ ID NOs: 46-55and 130.

In one embodiment, the secretion peptide is encoded by a polynucleotidesequence having at least 97% identity with any one of SEQ ID NOs: 46-55and 130.

In one embodiment, the secretion peptide is encoded by a polynucleotidesequence having at least 96% identity with any one of SEQ ID NOs: 46-55and 130.

In one embodiment, the secretion peptide is encoded by a polynucleotidesequence having at least 95% identity with any one of SEQ ID NOs: 46-55and 130.

In one embodiment, the secretion peptide is encoded by a polynucleotidesequence having at least 90%, at least 91%, at least 92%, at least 93%,at least 94%, or at least 95% identity with any one of SEQ ID NOs: 46-55and 130.

In one embodiment, the secretion tag is encoded by a polynucleotidesequence that represents a codon optimized version of SEQ ID NO: 46. Insome embodiments, the sequence for the codon optimized polynucleotidesequence is as follows (SEQ ID NO: 130):

ATGAGATTCCCATCCATCTTCACTGCTGTTTTGTTCGCTGCTTCTTCCGCTTTGGCTGCTCCAGTTAACACTACTACTGAGGACGAGACTGCTCAGATTCCAGCTGAAGCTGTTATTGGTTACTCCGACTTGGAAGGTGACTTCGACGTTGCTGTTTTGCCATTCTCCAACTCCACTAACAACGGTTTGTTGTTCATCAACACTACAATCGCTTCCATTGCTGCTAAAGAAGAGGGAGTTTCCTT GGAGAAGAGAGAGGCTGAAGCT

In another embodiment, the secretion peptide comprises a polypeptidesequence as set forth in any one of SEQ ID NOs: 116-125 or a polypeptidesequence having at least 90%, 95%, 98%, 99%, or 100% identity with anyone of SEQ ID NOs: 116-125.

In one embodiment, the secretion peptide comprises a polypeptidesequence having at least 99% identity with any one of SEQ ID NOs:116-125.

In one embodiment, the secretion peptide comprises a polypeptidesequence having at least 98% identity with any one of SEQ ID NOs:116-125.

In one embodiment, the secretion peptide comprises a polypeptidesequence having at least 97% identity with any one of SEQ ID NOs:116-125.

In one embodiment, the secretion peptide comprises a polypeptidesequence having at least 96% identity with any one of SEQ ID NOs:116-125.

In one embodiment, the secretion peptide comprises a polypeptidesequence having at least 95% identity with any one of SEQ ID NOs:116-125.

In one embodiment, the secretion peptide comprises a polypeptidesequence having at least 90% identity, at least 91% identity, at least92% identity, at least 93% identity, or at least 94% identity with anyone of SEQ ID NOs: 116-125.

In one embodiment, the vector encodes a polynucleotide for apurification and/or a detection tag. In another embodiment, thepurification and/or detection tag is selected from the group consistingof a human influenza hemagglutinin (HA) tag, a His 6 tag, and an HN tag.In one embodiment, the purification tag is encoded by a polynucleotidesequence as set forth in any one of SEQ ID NOs: 56-58 and 129. Inanother embodiment, the purification tag encodes a polypeptide as setforth in any one of SEQ ID NOs: 126-128.

In one embodiment, the recombinant vector is a plasmid. Exemplaryplasmids include the pPIC 3.5 and pL, represented by SEQ ID NOs: 69 and70, respectively.

In one embodiment, the disclosure relates to a polynucleotide for theGOI as set forth in any one of SEQ ID NOs: 2-45. In another aspect, thedisclosure relates to a polynucleotide of the GOI comprising a sequencehaving at least 90%, 95%, 98%, 99%, or 99.9% identity with any one ofSEQ ID NOs: 2-45.

In one embodiment, the polynucleotide comprises a sequence having atleast 99.9% identity with any one of SEQ ID NOs: 2-45.

In one embodiment, the polynucleotide comprises a sequence having atleast 98% identity with any one of SEQ ID NOs: 2-45.

In one embodiment, the polynucleotide comprises a sequence having atleast 97% identity with any one of SEQ ID NOs: 2-45.

In one embodiment, the polynucleotide comprises a sequence having atleast 96% identity with any one of SEQ ID NOs: 2-45.

In one embodiment, the polynucleotide comprises a sequence having atleast 95% identity with any one of SEQ ID NOs: 2-45.

In one embodiment, the polynucleotide comprises a sequence having atleast 90%, at least 91%, at least 92%, at least 93%, or at least 94%identity with any one of SEQ ID NOs: 2-45.

In another aspect, the polynucleotide for the gene of interest (GOI) hasa sequence as set forth in any one of SEQ ID NOs: 2-45.

In one embodiment, a polynucleotide of SEQ ID NOs: 2-45 encodes apolypeptide of SEQ ID NOs: 72-115. In one embodiment, a polynucleotidesequence having 90%, 95%, 98%, or 99.9% identity to SEQ ID NOs: 2-45encodes a polypeptide with a sequence having at least at least 90%, 95%,98%, or 99.9% identity with any one of SEQ ID NOs: 72-115.

In one embodiment, the polypeptide has 99.9% identity to a polypeptideof SEQ ID NOs: 72-115.

In another embodiment, the polypeptide has 98% identity to a polypeptideof SEQ ID NOs: 72-115.

In another embodiment, the polypeptide has 97% identity to a polypeptideof SEQ ID NOs: 72-115.

In another embodiment, the polypeptide has 96% identity to a polypeptideof SEQ ID NOs: 72-115.

In another embodiment, the polypeptide has 95% identity to a polypeptideof SEQ ID NOs: 72-115.

In one embodiment, the polypeptide has 90% identity, 91% identity, 92%identity, 93% identity, or 94% identity to a polypeptide of SEQ ID NOs:72-115.

In another aspect, the present invention provides a polypeptidecomprising the amino acid sequence of any one of SEQ ID NOs: 72-115 oran amino acid sequence comprising at least 90% identity, 91% identity,92% identity, 93% identity, or 94% identity to a polypeptide of SEQ IDNOs: 72-115.

In some embodiments, a polypeptide of the present invention comprises analteration at one or more (e.g., several) amino acids in thepolypeptide, wherein at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13,14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31,32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49,50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67,68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85,86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102,103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116,117, 118, 119, 120, 121, 122, 123,124, 125, 126, 127,128, 129, 130, 131,132, 133, 134,135, 136, 137, 138, 139, 140, 141, 142,143, 144, 145,146,147, 148, 149, 150, 151, 152, 153,154, 155, 156, 157, 158, 159, 160,161,162, 162, 164, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173,174, 175, 176, 177, 178, 179, 180, 181, 182, 183, 184, 185, 186, 187,188, 189, 190, 191, 193, 194, 195, 196, 197, 198, 199, 200, or moreamino acids are altered. In one embodiment, the alteration is relativeto the reference polypeptide of SEQ ID NO: 71, wherein the alterationcomprises one or more substitutions, insertions, deletions, and/oradditions in the polypeptide relative to the reference polypeptide ofSEQ ID NO: 71.

In other embodiments, the invention includes an isolated, recombinant,substantially pure, or non-naturally occurring polypeptide having CBDAsynthase activity, wherein the polypeptide comprises an amino acidsequence comprising at least about 60%, 65%, 70%, 75%, 80%, 85%, 86%,87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100%sequence identity to any one of SEQ ID NOs: 72-115. In one embodiment,the polypeptide does not comprise the sequence of SEQ ID NO: 71. Inanother embodiment, the CBDA synthase activity is at least about 2 toabout 30-fold greater than the activity of a naturally occurringcannabis synthase or a synthase having the sequence of SEQ ID NO: 71.

The recombinant vector of the disclosure may also contain a selectable“marker gene”, which facilitates the selection of host cells transformedor transfected with a recombinant cassette of the application. Examplesof selectable marker genes are genes encoding for proteins such as G418and hygromycin which confer resistance to certain drugs,β-galactosidase, chloramphenicol acetyltransferase, firefly luciferase,or an immunoglobulin or portion thereof such as the Fc portion of animmunoglobulin, optionally IgG. Transcription of the selectable markergene is monitored by changes in the concentration of the selectablemarker protein such as β-galactosidase, chloramphenicolacetyltransferase, or firefly luciferase. If the selectable marker geneencodes a protein conferring antibiotic resistance, such as neomycin,resistance transformant cells can be selected with G418. Cells that haveincorporated the selectable marker gene will survive, while the othercells die. In another embodiment, the selectable marker is introduced tothe host expression system on a separate vector from the recombinantvector of interest.

The recombinant vectors of the disclosure can be introduced into a hostcell or a host expression system to produce a transformed host cell.Prokaryotic and/or eukaryotic cells can be transformed with nucleic acidby, for example, electroporation or calcium chloride-mediatedtransformation. For example, the vector can be introduced into mammaliancells via conventional techniques such as calcium phosphate or calciumchloride co-precipitation, DEAE-dextran mediated transfection,lipofectin, viral mediated methods, electroporation or microinjection.Suitable methods for transforming and transfecting cells can be found inSambrook et al. (Molecular Cloning: A Laboratory Manual, 3rd Edition,Cold Spring Harbor Laboratory Press, 2001), and other laboratorytextbooks.

Suitable host cells include a wide variety of eukaryotic cells andprokaryotic cells. For example, the nucleic acids and proteins of thedisclosure may be expressed in plant cells, yeast cells or mammaliancells. In one embodiment, plant cells are of the genus Cannabis, forexample Cannabis saliva L, Cannabis indica Lam, and Cannabis ruderalisJanisch, especially Cannabis sativa. Microorganisms are preferablybacteria (e.g. Escherichia coli) or yeast (e.g. Saccharomycescerevisiae, Pichia pastoris). Insect cells are preferably Spodopterafrugiperda cells. The eukaryotic cell, in one embodiment, is a yeastcell.

Therefore, in another aspect, the disclosure provides a host expressionsystem comprising the recombinant vector as disclosed herein. In oneembodiment, the host expression system comprises a microbial cell, ayeast cell, a plant cell, or an animal cell. In another embodiment, thehost expression system comprises a yeast cell. In one embodiment, theyeast comprises one or more of Pichia pastoris, Pichia angusta, Pichiaguillermordii, Pichia methanolica, Pichia inositovera, Hansenulapolymorpha, Candida boidinii, and Yarrowia lipolytica.

Accordingly, also provided herein is a recombinant cell comprising therecombinant vector or the polynucleotide of this disclosure. In oneembodiment, the recombinant cell results in production of thepolypeptide of this disclosure.

In another embodiment, the present disclosure provides a method ofproducing a Cannabidiolic acid (CBDA) synthase or its variants, whichcomprises expressing the recombinant vector as disclosed above in thehost expression system.

In one embodiment, a method of producing a Cannabidiolic acid (CBDA)synthase or its variants comprises expressing the recombinant vectorwith a polynucleotide sequence as set forth in any one of SEQ ID NOs:2-45.

In an embodiment, the method of producing a Cannabidiolic acid (CBDA)synthase or its variants comprises expressing the recombinant vectorwith a polynucleotide sequence having at least 90%, 95%, 98%, or 99.9%identity with any one of SEQ ID NOs: 2-45.

In an embodiment, the method of producing a Cannabidiolic acid (CBDA)synthase or its variants comprises expressing the recombinant vectorwith a polynucleotide sequence with at least 99.9% identity with any oneof SEQ ID NOs: 2-45.

In an embodiment, the method of producing a Cannabidiolic acid (CBDA)synthase or its variants comprises expressing the recombinant vectorwith a polynucleotide sequence with at least 98% identity with any oneof SEQ ID NOs: 2-45.

In an embodiment, the method of producing a Cannabidiolic acid (CBDA)synthase or its variants comprises expressing the recombinant vectorwith a polynucleotide sequence with at least 95% identity with any oneof SEQ ID NOs: 2-45.

In an embodiment, the method of producing a Cannabidiolic acid (CBDA)synthase or its variants comprises expressing the recombinant vectorwith a polynucleotide sequence with at least 90% identity with any oneof SEQ ID NOs: 2-45.

In an embodiment, the method of producing a Cannabidiolic acid (CBDA)synthase or its variants comprises expressing the recombinant vectorwith a polynucleotide sequence with at least 85%, 86%, 87%, 88% or 89%identity with any one of SEQ ID NOs: 2-45.

According to an embodiment, the recombinant vector with a polynucleotidesequence as set forth in any one of SEQ ID NOs: 2-45 encodes apolypeptide of SEQ ID NOs: 72-115 or a polypeptide with at least 90%,95%, 98%, or 99% identity with any one of SEQ ID NOs: 72-115.

In one embodiment, the recombinant vector with a polynucleotide sequenceas set forth in any one of SEQ ID NOs: 2-45 encodes a polypeptide withat least 99.9% identity with any one of SEQ ID NOs: 72-115.

In one embodiment, the recombinant vector with a polynucleotide sequenceas set forth in any one of SEQ ID NOs: 2-45 encodes a polypeptide withat least 98% identity with any one of SEQ ID NOs: 72-115.

In one embodiment, the recombinant vector with a polynucleotide sequenceas set forth in any one of SEQ ID NOs: 2-45 encodes a polypeptide withat least 95% identity with any one of SEQ ID NOs: 72-115.

In one embodiment, the recombinant vector with a polynucleotide sequenceas set forth in any one of SEQ ID NOs: 2-45 encodes a polypeptide withat least 90% identity with any one of SEQ ID NOs: 72-115.

In one embodiment, the recombinant vector with a polynucleotide sequenceas set forth in any one of SEQ ID NOs: 2-45 encodes a polypeptide withat least 85%, 86%, 87%, 88% or 89% identity with any one of SEQ ID NOs:72-115.

In one embodiment the recombinant vector comprises a promoter of SEQ IDNo. 59 operably linked to a secretion tag of SEQ ID No. 46 which isoperably linked to the gene of interest of SEQ ID No. 5 operably linkedto Seq ID No. 56.

In one embodiment the recombinant vector comprises a promoter of SEQ IDNo. 60 operably linked to a secretion tag of SEQ ID No. 46 which isoperably linked to the gene of interest of SEQ ID No. 5 operably linkedto Seq ID No. 56.

In one embodiment the recombinant vector comprises a promoter of SEQ IDNo. 63 operably linked to a secretion tag of SEQ ID No. 46 which isoperably linked to the gene of interest of SEQ ID No. 5 operably linkedto Seq ID No. 56.

In one embodiment the recombinant vector comprises a promoter of SEQ IDNo. 64 operably linked to a secretion tag of SEQ ID No. 46 which isoperably linked to the gene of interest of SEQ ID No. 5 operably linkedto Seq ID No. 56.

In one embodiment the recombinant vector comprises a promoter of SEQ IDNo. 59 operably linked to a secretion tag of SEQ ID No. 46 which isoperably linked to the gene of interest of SEQ ID No. 13 operably linkedto Seq ID No. 56.

In one embodiment the recombinant vector comprises a promoter of SEQ IDNo. 60 operably linked to a secretion tag of SEQ ID No. 46 which isoperably linked to the gene of interest of SEQ ID No. 13 operably linkedto Seq ID No. 56.

In one embodiment the recombinant vector comprises a promoter of SEQ IDNo. 63 operably linked to a secretion tag of SEQ ID No. 46 which isoperably linked to the gene of interest of SEQ ID No. 13 operably linkedto Seq ID No. 56.

In one embodiment the recombinant vector comprises a promoter of SEQ IDNo. 64 operably linked to a secretion tag of SEQ ID No. 46 which isoperably linked to the gene of interest of SEQ ID No. 13 operably linkedto Seq ID No. 56.

In one embodiment, a method for producing a cannabinoid compoundcomprises reacting a cannabinoid precursor with an enzyme that isexpressed by a host expression system comprising a recombinant vectorthat has a promoter operably linked to a secretion tag that is operablylinked to a GOI, wherein the cannabinoid precursor is a compound ofFormula I:

wherein R₁ is H or —COOH and R₂ is a linear or branched CH₃, C₂H₅, C₃H₇,C₄H₉, C₅H₁₀, C₆H₁₃, C₇H₁₅ or C₈H₁₇ group.

In one embodiment, the recombinant vector comprises a GOI having apolynucleotide sequence as set forth in any one of SEQ ID NOs: 2-45.

In an embodiment, the recombinant vector comprises a polynucleotidesequence with at least 90%, 95%, 98%, or 99.9% identity with any one ofSEQ ID NOs: 2-45.

In one embodiment, the recombinant vector with a polynucleotide sequenceas set forth in any one of SEQ ID NOs: 2-45 encodes a polypeptide as setforth in any one of SEQ ID NOs: 72-115.

In one embodiment, the recombinant vector with a polynucleotide sequenceas set forth in any one of SEQ ID NOs: 2-45 encodes a polypeptide withat least 90%, 95%, 98%, or 99.9% identity with any one of SEQ ID NOs:72-115.

In one embodiment, the cannabinoid compound produced by a methoddescribed in this application is isolated and/or purified using chemicalpurification protocols well known in the art. In one embodiment, R₂ isC₃H₇ or C₅H₁₀. In one embodiment, R₂ is C₃H₇ and R₁ is —COOH or andester. In one embodiment, R₂ is C₅H₁₁ and R₁ is —COOH or and ester, forexample a C₁-C₁₀ alkyl ester, an optionally substituted aryl or benzylester. In another embodiment, the cannabinoid precursor is CBGVA, CBGA,and ester of CBGA or CBGVA, or derivatives and analogs of CBGA andCBGVA.

EXPERIMENTAL EXAMPLES

The invention is further described in detail by reference to thefollowing experimental examples. These examples are provided forpurposes of illustration only and are not intended to be limiting unlessotherwise specified. Thus, the invention should in no way be construedas being limited to the following examples, but rather, should beconstrued to encompass any and all variations which become evident as aresult of the teaching provided herein.

Without further description, it is believed that one of ordinary skillin the art can, using the preceding description and the followingillustrative examples, make and utilize the compounds of the presentinvention and practice the claimed methods. The following workingexamples therefore, specifically point out the preferred embodiments ofthe present invention, and are not to be construed as limiting in anyway the remainder of the disclosure.

Example 1 Molecular Cloning

An array of promoters was employed to drive the expression of the nativeand mutant CBDA synthase enzymes. The suitable promoters include, butare not limited to: alcohol oxidase 1 promoter (pAOX1), alcohol oxidase2 promoter (pAOX2), NAD⁺-dependent formylglutathione dehydrogenasepromoter (pFDH), peroxin Pex14p promoter (pPEX14),S-hydroxymethyl-glutathione hydrolase promoter (pFGH), dihydroxyacetonekinase promoter (pDAK), fructose 1,6-bisphosphate aldolase promoter(pFBA2), peroxisomal protein Pex8p promoter (pPEX8), peroxisomalmembrane signal receptor PTS1 promoter (pPEX5) and alcohol dehydrogenase2 promoter (pADH2). In one embodiment, the pAOX1 promoter was cloned tothe standard plasmid pPIC3.5 (Invitrogen) with the BglII and EcoRIrestriction sites, yielding a derivative called plasmid pL. DH5alpha E.coli strain was used for cloning and plasmid amplification.Transformation was performed according to a standard heat-shock protocolas known in the art.

In order to get the enzyme to secrete into the culture medium, asecretion peptide was fused to the 5′ of the GOI (gene of interest) inframe. Suitable secretion tags include but are not limited to α-MF(alpha mating factor from S. cerevisiae yeast), HSP150 (Heat shockprotein 150 from P. pastoris yeast), combination of pre-α-MF (19 aminoacids from α-MF) and the pro-region of HSP150 from P. pastoris,combination of pre-α-MF and a double repeat of the pro-region of HSP150from P. pastoris, SUC2 (invertase from S. cerevisiae), PHO1 (acidphosphatase from S. cerevisiae), PIR1 (55 amino acids from Protein withinternal repeats 1, from P. pastoris), OST1(dolichyl-diphosphooligosaccharide protein glycotransferase subunitOST1), OST1 fused to the pro-region of the α-MF secretion peptide (20-85amino acids of the α-MF secretion peptide) and DDDK (first 18 aminoacids from protein AOA68487.1:GenBank accession No. from P. pastoris).

In one embodiment, the secretion tag, and the gene for CBDA synthase orits mutants were synthesized as one construct. In another embodiment, aPCR based method was used to fuse the desired secretion tag to the codonoptimized gene of CBDA synthase and mutants of this enzyme. The genesfor the CBDA synthase and its mutants were chemically synthesized(Thermo Fisher Scientific, USA), and sequences of these constructs wereverified with Sanger sequencing (Eurofins Genomics).

To process a secretion tagged construct (i.e., cleavage of the signalpeptide from the nascent peptide chain), the cleavage recognition aminoacid sequence (lysine-arginine) of Kex2 protease was introduceddownstream of each secretion peptide. Thus, all secretion peptides wereflanked with a lysine-arginine (KR) or lysine-lysine (KK) pair at theC-terminus, upstream of the respective GOI. To increase efficiency ofcleavage by Kex2 protease, the amino acid pairs LE (leucine-glutamicacid) or ME (Methionine-glutamic acid) were cloned upstream of KR or KKflanks. Downstream of KR or KK cleavage site an EAEA repeat (glutamicacid-alanine-glutamic acid-alanine) was cloned, which is processed(sequentially cleaved) by the aminopeptidyl peptidase.

Transformation into Yeast Strain

Plasmids were linearized (cut) within their promoter sequence usingSacI/BamHI/another restriction enzyme, depending on the promoter used.The linearized plasmids were transformed individually into the GS 115strain of the yeast, Pichia pastoris. Following transformation, theyeast cells was plated onto YPD (Yeast Extract-Peptone-Dextrose) platescontaining geneticin (G418≥0.25 mg/ml) to enable ‘antibiotic resistance’based selection of the transformed yeast colonies. The successfulintegration of the respective GOI was subsequently verified using colonyPCR. FIG. 1 schematically illustrates the construct containing the GOIand its integration within the yeast genome.

Colony screening and growth experiment with the shaking flasks Selectedclones (colonies) were streaked from the transformation plates intofresh YPD plates containing geneticin (G418≥0.25 mg/ml) to obtainmonoclonal colonies. Each monoclonal colony was then subjected to serialplating onto YPD plates with increasing geneticin concentration (up to 3mg/ml) to obtain a set of clones with variable gene copy number withrespect to the gene of interest. Subsequently, at least 10 suchmonoclonal colonies were chosen to be individually tested in shake flaskstudies. Note that glycerol stocks were also made for these selectedmonoclonal colonies using standard procedure to enable long term storageat −80° C.

Shake flask studies were initiated with at least 10 monoclonal coloniesfor each new construct in parallel with appropriate referencecontrol(s). Each individual colony (grown as a biomass on YPD plates)was inoculated into a shake flask containing 10 mls of BMGY (BufferedGlycerol-complex) medium and incubated for 24 hours at 30° C., withshaking at 270 rpm. After 24-hours the cultures were induced for 3consecutive days with a daily dose of either a final concentration of0.2% potassium formate+0.5-1% sorbitol or 0.25-1% methanol. In somecases, a daily double dose of 0.2% potassium formate+0.5-1% sorbitol wasfed to the cultures.

Enzyme Assay

At the end of 70-72 hours, shake flask cultures of cells were subjectedto centrifugation at 10,000 g for five minutes. The supernatant wascollected and the activity of the enzyme in the supernatant was measuredusing an HPLC based enzyme assay. In one embodiment, the activity of theenzyme in the supernatant was measured by setting up the reactionmixture that included 125 μl of 200 mM sodium citrate buffer (pH 4.8),50-100 μl of the supernatant and 25 μl of a 554 μM solution ofCannabigerolic acid (CBGA) in DMSO. Note that the substrate (e.g., CBGA)concentration used in the assay can vary from 554 μM-2.7 mM.

Following incubation at 30° C. for 30 mins, the reaction was stopped bythe addition of 250 μl of 100% methanol (1:1 MeOH: vol. of reactionmixture). The stopped reaction was then centrifuged at 14000 rpm for 15mins and the supernatant analyzed by HPLC. In one embodiment thesupernatant comprising the enzyme is incubated with a substrate, forexample, CBGA or CBGVA for 1-16 hours, preferably for 1-15 hours,preferably for 1-14 hours, preferably for 1-13 hours, preferably for1-12 hours, preferably for 1-11 hours, preferably for 1-10 hours,preferably for 1-9 hours, preferably for 1-8 hours, preferably for 1-7hours, preferably for 1-6 hours, preferably for 1-5 hours, preferablyfor 1-4 hours, preferably for 1-3 hours, or preferably for 1-2 hours.

HPLC

HPLC was performed on the Agilent 1260 Infinity II system. Mobile PhaseA refers to water with 0.1% formic acid while the mobile Phase B refersto acetonitrile with 0.1% formic acid. Each new run on the HPLC startswith a one-hour equilibration at 25% A and 75% B. To ensure that thesystem was thoroughly cleaned and there was no carryover, prior to theanalysis of a new set of samples the column was cleaned by injectingpure methanol followed by an injection of DMSO. Such a cleaning routinewas carried out once every 20 samples. The injection volume was set at20 μl and the flow rate of the mobile phase was set at 400 μl/min.Samples were analyzed using the following gradient:

-   -   0.0 min 25% A, 75% B,    -   5.00 min: 4% A, 96% B,    -   5.01 min: 0% A, 100% B, and    -   6.00 min: 0% A, 100% B.

10 μl of 0.01 mg/mL of Δ8-THC (Cerilliant T-032 at 1 mg/mL diluted with100% methanol) was added as an internal standard to each sample andmixed five times within the injector compartment prior to loading ontothe column. Calibration curves for CBGA (Cerilliant C-142 at 1 mg/mLdiluted with 100% methanol), CBDA (Cerilliant C-144 at 1 mg/mL dilutedwith 100% methanol), and Δ9-THCA-A (Cerilliant T-093 at 1 mg/mL dilutedwith 100% methanol) were generated separately and were used to calculatethe amount of CBGA, CBDA and/or Δ9-THCA-A produced in a test sample byan enzyme of the present disclosure. Prior to, and following eachinjection, the injection needle was washed for 3 seconds with 100% MeOH.The column chamber was set to a temperature of 30.0±0.8° C. while theDiode Array Detector (DAD) was set to scan from 190 nm to 400 nm withdata primarily collected at 269 nm with a peak width of 5 Hz (>0.05min). Data was analyzed using Agilent OpenLab CDS running on Windows 10.

The sequences of this disclosure are provided with the Referencesequence numbered as SEQ ID NO: 1 or 71.

Table 1 shows enzyme assay data.

TABLE 1 Enzyme activity relative to SEQ ID 71 (Reference) SEQ ID NOs:≥5-fold 75, 76, 78, 79, 80, 83, 84, 86, 87, 92, 93, 97, 98, 99 <5-fold72, 73, 74, 77, 81, 82, 85, 88-91, 94, 95, 96, 100, 101 Not determined102-115

Table 2 correlates the SEQ ID numbers of the polynucleotide sequencesfor various accessory elements used to produce the CBDA synthase mutantsaccording to this disclosure to the SEQ ID numbers of theircorresponding polypeptide (protein) sequences.

TABLE 2 Corresponding Nucleotide Amino Acid SEQ ID No. SEQ ID No.Accessory Element SEQ ID No. 46 SEQ ID No. 116 Secretion peptidealpha-MF (alpha mating factor from S. cerevisiae yeast) SEQ ID No. 47SEQ ID No. 117 Secretion peptide HSP150 (Heat shock protein 150 from P.pastoris yeast) SEQ ID No. 48 SEQ ID No. 118 Secretion peptide:combination of pre region of alpha -MF (19 amino acids from alpha -MF)and pro-region of HSP150 from P. pastoris SEQ ID No. 49 SEQ ID No. 119Secretion peptide: combination of pre region of alpha -MF and doublerepeat of pro-region of HSP150 SEQ ID No. 50 SEQ ID No. 120 Secretionpeptide SUC2 (invertase from S. cerevisiae) SEQ ID No. 51 SEQ ID No. 121Secretion peptide PHO1 (acid phosphatase from S. cerevisiae) SEQ ID No.52 SEQ ID No. 122 Secretion peptide PIR1 (55 amino acids from Proteinwith internal repeats 1, from P. pastoris SEQ ID No. 53 SEQ ID No. 123Secretion peptide OST1 (dolichyl-diphosphooligosaccharide proteinglycotransferase subunit OST1) SEQ ID No. 54 SEQ ID No. 124 Secretionpeptide OST1 fused to pro-region of alpha -MF secretion peptide (20-85amino acids of alpha -MF secretion peptide) SEQ ID No. 55 SEQ ID No. 125Secretion peptide DDDK (first 18 amino acids from protein with accessnumber AOA68487.1 from P. pastoris) SEQ ID No. 56 SEQ ID No. 126 Humaninfluenza hemagglutinin (HA) tag or 129 SEQ ID No. 57 SEQ ID No. 127 6XHistidine tag SEQ ID No. 58 SEQ ID No. 128 HN tag SEQ ID No. 59 Notapplicable Promoter pAOX1 (alcohol oxidase 1) SEQ ID No. 60 Notapplicable Promoter pAOX2 (alcohol oxidase 2) SEQ ID No. 61 Notapplicable Promoter pFDH (NAD⁺-dependent formylglutathionedehydrogenase) SEQ ID No. 62 Not applicable Promoter pPEX14 (peroxinPex14p) SEQ ID No. 63 Not applicable Promoter pFGH(S-hydroxymethyl-glutathione hydrolase) SEQ ID No. 64 Not applicablePromoter pDAK (dihydroxyacetone kinase) SEQ ID No. 65 Not applicablePromoter pFBA (fructose 1,6-bisphosphate aldolase) SEQ ID No. 66 Notapplicable Promoter pPEX5 (peroxisomal membrane signal receptor PTS1)SEQ ID No. 67 Not applicable Promoter pADH2 (alcohol dehydrogenase 2)SEQ ID No. 68 Not applicable Promoter pPEX8 (peroxisomal protein Pex8p)SEQ ID No. 69 Not applicable Plasmid pPIC 3.5 SEQ ID No. 70 Notapplicable Plasmid pL

(ORIGINAL/REFERENCE CBDAS) SEQ ID NO: 1AACCCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCAAACAACGCTACAAACTTGAAGTTGGTTTACACTCAGAACAACCCATTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACTTCCGACACTACTCCAAAGCCATTGGTTATCGTTACTCCATCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCTTTCGTTATCGTTGACTTGAGAAACATGAGATCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCTGGTGCTACTTTGGGTGAAGTTTACTACTGGGTTAACGAGAAGAACGAGAACTTGTCCTTGGCTGCTGGTTACTGTCCAACTGTTTGTGCTGGTGGTCATTTCGGTGGTGGTGGTTATGGTCCATTGATGAGAAACTACGGTTTGGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGTGAGGACTTGTTCTGGGCTTTGAGAGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGATTGGTTGCTGTTCCAAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGATTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAGACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGTATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTTAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGACAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGTATGTACGCTTTGTACCCATACGGTGGTATCATGGACGAAATTTCCGAGTCCGCTATTCCATTCCCACACAGAGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAGAACCCAAGATTGGCTTACTTGAACTACAGAGACTTGGACATCGGAATCAACGACCCAAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCAAACAATTTCTTCAGAAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 2AACCCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCAAACAACGCTACAAACTTGAAGTTGGTTTACACTCAGAACAACCCATTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACTTCCGACACTACTCCAAAGCCATTGGTTATCGTTACTCCATCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCTTTCGTTATCGTTGACTTGAGAAACATGAGATCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCTGGTGCTACTTTGGGTGAAGTTTACTACTGGGTTAACGAGAAGAACGAGAACTTGTCCTTGGCTGCTGGTTACTGTCCAACTGTTGGTGCTGGTGGTCATTTCGGTGGTGGTGGTTATGGTCCATTGATGAGAAACTACGGTTTGGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGTGAGGACTTGTTCTGGGCTTTGAGAGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGATTGGTTGCTGTTCCAAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGATTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAGACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGTATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTTAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGACAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGTATGTACGCTTTGTACCCATACGGTGGTATCATGGACGAAATTTCCGAGTCCGCTATTCCATTCCCACACAGAGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAGAACCCAAGATTGGCTTACTTGAACTACAGAGACTTGGACATCGGAATCAACGACCCAAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCAAACAATTTCTTCAGAAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 3AACCCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCAAACAACGCTACAAACTTGAAGTTGGTTTACACTCAGAACAACCCATTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACTTCCGACACTACTCCAAAGCCATTGGTTATCGTTACTCCATCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCTTTCGTTATCGTTGACTTGAGAAACATGAGATCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCTGGTGCTACTTTGGGTGAAGTTTACTACTGGGTTAACGAGAAGAACGAGAACTTGTCCTTGGCTGCTGGTTACTGTCCAACTGTTTGTGCTGGTGGTCATTTCGGTGGTGGTGGTTATGGTCCATTGATGAGAAACTACGGTTTGGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGTGAGGACTTGTTCTGGGCTTTGAGAGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGATTGGTTGCTGTTCCAAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGATTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAGACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGTATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTTAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGACAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGTATGTACGCTTTGTACCCATACGGTGGTATCATGGACGAAATTTCCGAGTCCGCTATTCCATTCCCACACAGAGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCCAGAACCCAAGATTGGCTTACTTGAACTACAGAGACTTGGACATCGGAATCAACGACCCAAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCAAACAATTTCTTCAGAAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 4AACCCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCAAACAACGCTACAAACTTGAAGTTGGTTTACACTCAGAACAACCCATTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCATTTCCGACACTACTCCAAAGCCATTGGTTATCGTTACTCCATCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCTTTCGTTATCGTTGACTTGAGAAACATGAGATCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCTGGTGCTACTTTGGGTGAAGTTTACTACTGGGTTAACGAGAAGAACGAGAACTTGTCCTTGGCTGCTGGTTACTGTCCAACTGTTTGTGCTGGTGGTCATTTCGGTGGTGGTGGTTATGGTCCATTGATGAGAAACTACGGTTTGGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGTGAGGACTTGTTCTGGGCTTTGAGAGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGATTGGTTGCTGTTCCAAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGATTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAGACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGTATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTTAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGACAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGTATGTACGCTTTGTACCCATACGGTGGTATCATGGACGAAATTTCCGAGTCCGCTATTCCATTCCCACACAGAGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCCAGAACCCAAGATTGGCTTACTTGAACTACAGAGACTTGGACATCGGAATCAACGACCCAAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCAAACAATTTCTTCAGAAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 5AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 6AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAAGCGGTGCTACATTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCTCTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGGTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 7AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAAGCGGTGCTACATTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCTCTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGGTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTAAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 8AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCAAGCACATCCCCAACAACGTTGCTAACCCTAAGTTGGTATACACTCAGCACGACCAGTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 9AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCGGCAACAGGGGTAATGTATACACTCAGCACGACCAGTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 10AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACGCTAACCCTAAGTTGGTATACACTCAGCACGACCAGTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 11AACGCAAGAGAAAACTTGTTGAAGTGTTTGTCCCAGCACGGTGACGGCACAGGAAAGACAGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCAAGATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 12AACGCAAGAGAAAACTTGTTGAAGTGTTTGTCCCAGCACGACGGCACAGGAAAGACAGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCAAGATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 13AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 14AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 15AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTCTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 16AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACGATGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTTCCTGGTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 17AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGGACCTCTCCTTTCCTGGTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCTCAACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 18AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACGATGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAAAATTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAAATATGGAAATCCACGCTTTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACGTTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 19AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGAGGCACAGGAAGTGGAACCTTCAAGAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 20AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGAGGCACAGGAAGTGGAACCAAGAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 21AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGGCGATGGAACAGGTAAGAAAGAGATCTTGTTGGACAGATCCGCTAAGGGCAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 22AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATCTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAAGAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTCTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTAAGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 23AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTTCTGTTTTGGACAGACAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGCAACCAATCCCAGAGTCCGTTTTCGTTAAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 24AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACCCTACACCCAATACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 25AACGCAAGAGAAGACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAAGTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAAACGGAGCTATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACGAAGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTAAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAAAGTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 26AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACCAATCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTTTGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAAATGTCGAAATCCACGCTTTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTACAGTTTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 27AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGGACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 28AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACGACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGGACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 29AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACGACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGCAAAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 30AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGGACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAAGCGGTGCTACATTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCTCTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGGTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTAAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 31AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCTGTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACGACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 32AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAAAACTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 33AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGATTCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 34AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGATAACTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 35AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGGACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 36AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATCTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAAGAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTCTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTAAGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 37AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACGATGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTTCCTGGTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 38AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGCACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGGACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCAACGTTGCCCACATCCAGGCTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATCTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAAGAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTCTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTAAGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 39AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACGCTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 40AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACACTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 41AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACCCTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 42AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTCTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAACGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 43AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATAC ACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCAGAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAAAGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 44AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCAGAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAGAGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 45AACGCAAGAGAAAACTTCTTGAAGTGTTTTTCCCAGTACATCCCCAACAACGCTACAAACTTGAAGTTGGTATACACTCAGAATAATCCCTTGTACATGTCCGTTTTGAACTCCACAATCCACAACTTGAGATTCACATCCGACACTACTCCAAAGCCCTTGGTTATCGTTACTCCCTCCCACGTTTCCCACATCCAGGGTACTATTTTGTGTTCCAAGAAGGTTGGATTGCAGATCAGAACAAGATCCGGTGGTCACGACTCTGAAGGTATGTCCTACATTTCCCAGGTTCCCTTCGTTATCGTTGACCTTAGAAACATGCGTTCCATCAAGATCGACGTTCACTCCCAGACTGCTTGGGTTGAAGCAGGTGCTACGTTGGGTGAAGTTTATTACTGGGTTAACGAGAAGAACGAGAACCTCTCCTTGGCCGCTGGTTACTGTCCAACCGTTGGTGCTGGTGGTCATTTCGGTGGAGGTGGTTATGGTCCATTGATGAGAAACTACGGACTTGCTGCTGACAACATCATCGACGCTCACTTGGTTAACGTTCACGGTAAGGTTTTGGACAGAAAGTCCATGGGAGAGGACTTGTTCTGGGCTTTGCGTGGTGGTGGTGCTGAATCCTTCGGTATTATCGTTGCTTGGAAGATCAGACTTGTTGCTGTTCCCAAGTCCACTATGTTCTCCGTTAAGAAAATCATGGAAATCCACGAATTGGTTAAGTTGGTTAACAAGTGGCAGAACATTGCTTACAAGTACGACAAGGACTTGTTGTTGATGACTCACTTCATCACTAGAAACATCACTGACAACCAGGGTAAGAACAAAACTGCTATCCACACTTACTTCTCTTCCGTTTTCTTGGGTGGTGTTGACTCCTTGGTTGATTTGATGAACAAGTCCTTCCCAGAGTTGGGCATCAAGAAAACTGACTGTAGACAGTTGTCCTGGATCGACACTATCATCTTCTACTCCGGTGTTGTAAACTACGACACAGACAACTTCAACAAAGAGATCTTGTTGGACAGATCCGCTGGCCAGAGAGGTGCTTTCAAGATCAAGTTGGACTACGTTAAGAAGCCAATCCCAGAGTCCGTTTTCGTTCAGATTTTGGAGAAGTTGTACGAAGAGGACATCGGTGCTGGAATGTACGCTTTGTACCCTTACGGTGGCATCATGGACGAAATCTCCGAGTCCGCTATTCCCTTCCCACACCGTGCTGGTATCTTGTACGAGTTGTGGTACATCGCTTCTTGGGAGAAGCAAGAGGACAACGAGAAGCACTTGAACTGGATCAGAAACATCTACAACTTCATGACTCCATACGTTTCCAAAAACCCTAGATTGGCATACCTAAACTACAGAGACTTGGACATCGGCATCAACGACCCCAAGAACCCTAACAACTACACTCAGGCTAGAATCTGGGGTGAAAAGTACTTCGGTAAGAACTTCGACAGATTGGTTAAGGTTAAGACTTTGGTTGACCCTAACAATTTCTTCAGGAACGAGCAGTCCATCCCTCCATTGCCAAGACATAGACATTAA SEQ ID NO: 46ATGAGATTTCCTTCAATTTTTACTGCAGTTTTATTCGCAGCATCCTCCGCATTAGCTGCTCCAGTCAACACTACAACAGAAGATGAAACGGCACAAATTCCGGCTGAAGCTGTCATCGGTTACTCAGATTTAGAAGGGGATTTCGATGTTGCTGTTTTGCCATTTTCCAACAGCACAAATAACGGGTTATTGTTTATAAATACTACTATTGCCAGCATTGCTGCTAAAGAAGAAGGGGTATCTCTCGAGAAAAGAGAGGCTGAAGCT SEQ ID NO: 47ATGCAATACAAAAAGACTTTGGTTGCCTCTGCTTTGGCCGCTACTACATTGGCCGCCTATGCTCCATCTGAGCCTTGGTCCACTTTGACTCCAACAGCCACTTACAGCGGTGGTGTTACCGACTACGCTTCCACCTTCGGTATTGCCGTTCAACCAATCTCCACTACATCCAGCGCATCATCTGCAGCCACCACAGCTAGCTTGGAGAAGAGGGAGGCTGATGCTSEQ ID NO: 48ATGAGATTCCCATCCATCTTCACTGCTGTTTTGTTCGCTGCTTCTTCCGCTTTGGCTGCTAGAGCCTATGCTCCATCTGAGCCTTGGTCCACTTTGACTCCAACAGCCACTTACAGCGGTGGTGTTACCGACTACGCTTCCACCTTCGGTATTGCCGTTCAACCAATCTCCACTACATCCAGCGCATCATCTGCAGCCACCACAGCCTCATCTgCTAGCTTGGAGAAGAGGGAGGCTGATGCT SEQ ID NO: 49ATGAGATTCCCATCCATCTTCACTGCTGTTTTGTTCGCTGCTTCTTCCGCTTTGGCTGCTCCAGTTAACACTACTACTGAGGACGAGACTGCTCAGATTCCAGCTGAAGCTGTTATTGGTTACTCCGACTTGGAAGGTGACTTCGACGTTGCTGTTTTGCCATTCTCCAACTCCACTAACAACGGTTTGTTGTTCATCAACACTACAATCGCTTCCATTGCTGCTAAAGAAGAGGGAGTTTCCTTGGAGAAGAGAGAGGCTGAAGCTCGCTGCTTCTTCCGCTTTGGCTGCTCCAGTTAACACTACTACTGAGGACGAGACTGCTCAGATTCCAGCTGAAGCTGTTATTGGTTACTCCGACTTGGAAGGTGACTTCGACGTTGCTGTTTTGCCATTCTCCAACTCCACTAACAACGGTTTGTTGTTCATCAACACTACAATCGCTTCCATTGCTGCTAAAGAAGAGGGAGTTTCCTTGGAGAAGAGAGAGGCTGAAGC SEQ ID NO: 50ATGCTTTTGCAAGCTTTCCTTTTCCTTTTGGCTGGTTTTGCAGCCAAAATATCTGCAGGATCCGCTAGCTTGGAGAAGAGGGAGGCTGAAGCT SEQ ID NO: 51ATGTTTTCTCCTATTCTAAGTCTGGAAATTATTCTCGCTTTGGCTACTCTCCAATCAGTCTTTGCGGCTAGCTTGGAGAAGAGGGAGGCTGAAGCT SEQ ID NO: 52TGTACAGGAACTTAATAATTGCTACTGCCCTTACTTGCGGTGCATACAGTGCCTACGTGCCTTCCGAACCATGGAGCACACTGACACCTGATGCTAGCCTTGAAAGTGCCCTCAAAGATTACTCACAAACTTTTGGAATAGCTATTAAGTCCTTAGATGCCGACGGATCCGCTAGCTTGGAGAAGAGGGAGGCTGAAGCT SEQ ID NO: 53ATGAGGCAGGTTTGGTTCTCTTGGATTGTGGGATTGTTCCTATGTTTTTTCAACGTGTCTTCTGCTGCTAGCTTGGAGAAGAGGGAGGCTGATGCT SEQ ID NO: 54ATGAGGCAGGTTTGGTTCTCTTGGATTGTGGGATTGTTCCTATGTTTTTTCAACGTGTCTTCTGCTGCTCCAGTTAACACTACTACTGAGGACGAGACTGCTCAGATTCCAGCTGAAGCTGTTATTGGTTACTCCGACTTGGAAGGTGACTTCGACGTTGCTGTTTTGCCATTCTCCAACTCCACTAACAACGGTTTGTTGTTCATCAACACTACAATCGCTTCCATTGCTGCTAAAGAAGAGGGAGCTAGCTTGGAGAAGAGGGAGGCTGATGCT SEQ ID NO: 55ATGTTCAACCTGAAAACTATTCTCATCTCAACACTTGCATCGATCGCTGTTGCCGCTAGCTTGGAGAAGAGGGAGGCTGATGCT SEQ ID NO: 56 TACCCATACGATGTTCCAGATTACGCT SEQ ID NO: 57CATCACCATCACCATCAC SEQ ID NO: 58 CATAACCATAATCACAATCACAAC SEQ ID NO: 59GATCTAACATCCAAAGACGAAAGGTTGAATGAAACCTTTTTGCCATCCGACATCCACAGGTCCATTCTCACACATAAGTGCCAAACGCAACAGGAGGGGATACACTAGCAGCAGACCGTTGCAAACGCAGGACCTCCACTCCTCTTCTCCTCAACACCCACTTTTGCCATCGAAAAACCAGCCCAGTTATTGGGCTTGATTGGAGCTCGCTCATTCCAATTCCTTCTATTAGGCTACTAACACCATGACTTTATTAGCCTGTCTATCCTGGCCCCCCTGGCGAGGTTCATGTTTGTTTATTTCCGAATGCAACAAGCTCCGCATTACACCCGAACATCACTCCAGATGAGGGCTTTCTGAGTGTGGGGTCAAATAGTTTCATGTTCCCCAAATGGCCCAAAACTGACAGTTTAAACGCTGTCTTGGAACCTAATATGACAAAAGCGTGATCTCATCCAAGATGAACTAAGTTTGGTTCGTTGAAATGCTAACGGCCAGTTGGTCAAAAAGAAACTTCCAAAAGTCGGCATACCGTTTGTCTTGTTTGGTATTGATTGACGAATGCTCAAAAATAATCTCATTAATGCTTAGCGCAGTCTCTCTATCGCTTCTGAACCCCGGTGCACCTGTGCCGAAACGCAAATGGGGAAACACCCGCTTTTTGGATGATTATGCATTGTCTCCACATTGTATGCTTCCAAGATTCTGGTGGGAATACTGCTGATAGCCTAACGTTCATGATCAAAATTTAACTGTTCTAACCCCTACTTGACAGCAATATATAAACAGAAGGAAGCTGCCCTGTCTTAAACCTTTTTTTTTATCATCATTATTAGCTTACTTTCATAATTGCGACTGGTTCCAATTGACAAGCTTTTGATTTTAACGACTTTTAACGACAACTTGAGAAGATCAAAAAACAACTAATTATTCGAAACG SEQ ID NO: 60TTATTTTTTGACCGAATTCTTTTTTTCAGACCATATGACCGGTCCATCTTCTACGGGGGGATTATCTATGCTTTGACCTCTATCTTGATTCTTTTATGATTCAAATCACTTTTACGTTATTTATTACTTACTGGTTATTTACTTAGCGCCTTTTCTGAAAAACATTTACTAAAAATCATACATCGGCACTCTCAAACACGACAGATTGTGATCAAGAAGCAGAGACAATCACCACTAAGGTTGCACATTTGAGCCAGTAGGCTCCTAATAGAGGTTCGATACTTATTTTGATAATACGACATATTGTCTTACCTCTGAATGTGTCAATACTCTCTCGTTCTTCGTCTCGTCAGCTAAAAATATAACACTTCGAGTAAGATACGCCCAATTGAAGGCTACGAGATACCAGACTATCACTAGTAGAACTTTGACATCTGCTAAAGCAGATCAAATATCCATTTATCCAGAATCAATTACCTTCCTTTAGCTTGTCGAAGGCATGAAAAAGCTACATGAAAATCCCCATCCTTGAAGTTTTGTCAGCTTAAAGGACTCCATTTCCTAAAATTTCAAGCAGTCCTCTCAACTAAATTTTTTTCCATTCCTCTGCACCCAGCCCTCTTCATCAACCGTCCAGCCTTCTCAAAAGTCCAATGTAAGTAGCCTGCAAATTCAGGTTACAACCCCTCAATTTTCCATCCAAGGGCGATCCTTACAAAGTTAATATCGAACAGCAGAGACTAAGCGAGTCATCATCACCACCCAACGATGGTGAAAAACTTTAAGCATAGATTGATGGAGGGTGTATGGCACTTGGCGGCTGCATTAGAGTTTGAAACTATGGGGTAATACATCACATCCGGAACTGATCCGACTCCGAGATCATATGCAAAGCACGTGATGTACCCCGTAAACTGCTCGGATTATCGTTGCAATTCATCGTCTTAAACAGTACAAGAAACTTTATTCATGGGTCATTGGACTCTGATGAGGGGCACATTTCCCCAATGATTTTTTGGGAAAGAAAGCCGTAAGAGGACAGTTAAGCGAAAGAGACAAGACAACGAACAGCAAAAGTGACAGCTGTCAGCTACCTAGTGGACAGTTGGGAGTTTCCAATTGGTTGGTTTTGAATTTTTACCCATGTTGAGTTGTCCTTGCTTCTCCTTGCAAACAATGCAAGTTGATAAGACATCACCTTCCAAGATAGGCTATTTTTGTCGCATAAATTTTTGTCTCGGAGTGAAAACCCCTTTTATGTGAACAGATTACAGAAGCGTCCTACCCTTCACCGGTTGAGATGGGGAGAAAATTAAGCGATGAGGAGACGATTATTGGTATAAAAGAAGCAACCAAAATCCCTTATTGTCCTTTTCTGATCAGCATCAAAGAATATTGTCTTAAAACGGGCTTTTAACTACATTGTTCTTACACATTGCAAACCTCTTCCTTCTATTTCGGATCAACTGTATTGACTACATTGATCTTTTTTAACGAAGTTTACGACTTACTAAATCCCCACAAACAAATCAACTGAGAAAA SEQ ID NO: 61TGAGATAACAGAGTTGGGTAACTAGAGAGAATAATAGACGTATGCATGATTACTACACAACGGATGTCGCACTCTTTCCTTAGTTAAAACTATCATCCAATCACAAGATGCGGGCTGGAAAGACTTGCTCCCGAAGGATAATCTTCTGCTTCTATCTCCCTTCCTCATATGGTTTCGCAGGGCTCATGCCCCTTCTTCCTTCGAACTGCCCGATGAGGAAGTCCTTAGCCTATCAAAGAATTCGGGACCATCATCGATTTTTAGAGCCTTACCTGATCGCAATCAGGATTTCACTACTCATATAAATACATCGCTCAAAGCTCCAACTTTGCTTGTTCATACAATTCTTGATATTCAC SEQ ID NO: 62ATTCTGGCCCTTGCACCTGATCGCGAAGGTGGAAATGGCAGAAGGATCAGCCTGGACGAAGCAACCAGTTCCAACTGCTAAGTAAAGAAGATGCTAGACGAAGGAGACTTCAGAGGTGAAAAGTTTGCAAGAAGAGAGCTGCGGGAAATAAATTTTCAATTTAAGGACTTGAGTGCGTCCATATTCGTGTACGTGTCCAACTGTTTTCCATTACCTAAGAAAAACATAAAGATTAAAAAGATAAACCCAATCGGGAAACTTTAGCGTGCCGTTTCGGATTCCGAAAAACTTTTGGAGCGCCAGATGACTATGGAAAGAGGAGTGTACCAAAATGGCAAGTCGGGGGCTACTCACCGGATAGCCAATACATTCTCTAGGAACCAGGGATGAATCCAGGTTTTTGTTGTCACGGTAGGTCAAGCATTCACTTCTTAGGAATATCTCGTTGAAAGCTACTTGAAATCCCATTGGGTGCGGAACCAGCTTCTAATTAAATAGTTCGATGATGTTCTCTAAGTGGGACTCTACGGCTCAAACTTCTACACAGCATCATCTTAGTAGTCCCTTCCCAAAACACCATTCTAGGTTTCGGAACGTAACGAAACAATGTTCCTCTCTTCACATTGGGCCGTTACTCTAGCCTTCCGAAGAACCAATAAAAGGGACCGGCTGAAACGGGTGTGGAAACTCCTGTCCAGTTTATGGCAAAGGCTACAGAAATCCCAATCTTGTCGGGATGTTGCTCCTCCCAAACGCCATATTGTACTGCAGTTGGTGCGCATTTTAGGGAAAATTTACCCCAGATGTCCTGATTTTCGAGGGCTACCCCCAACTCCCTGTGCTTATACTTAGTCTAATTCTATTCAGTGTGCTGACCTACACGTAATGATGTCGTAACCCAGTTAAATGGCCGAAAAACTATTTAAGTAAGTTTATTTCTCCTCCAGATGAGACTCTCCTTCTTTTCTCCGCTAGTTATCAAACTATAAACCTATTTTACCTCAAATACCTCCAACATCACCCACTTAAACA SEQ ID NO: 63ATCTTCATTGATGAAACGTTGTGATCGGTGTGACTTTTATAGTAAAAGCTACAACTGTTTGAAATACCAAGATATCATTGTGAATGGCTCAAAAGGGTAATACATCTGAAAAACCTGAAGTGTGGAAAATTCCGATGGAGCCAACTCATGATAACGCAGAAGTCCCATTTTGCCATCTTCTCTTGGTATGAAACGGTAGAAAATGATCCGAGTATGCCAATTGATACTCTTGATTCATGCCCTATAGTTTGCGTAGGGTTTAATTGATCTCCTGGTCTATCGATCTGGGACGCAATGTAGACCCCATTAGTGGAAACACTGAAAGGGATCCAACACTCTAGGCGGACCCGCTCACAGTCATTTCAGGACAATCACCACAGGAATCAACTACTTCTCCCAGTCTTCCTTGCGTGAAGCTTCAAGCCTACAACATAACACTTCTTACTTAATCTTTGATTCTCGAATTGTTTACCCAATCTTGACAACTTAGCCTAAGCAATACTCTGGGGTTATATATAGCAATTGCTCTTCCTCGCTGTAGCGTTCATTCCATCTTTCTA SEQ ID NO: 64TGTCATCTGCTGATGCTGTGAGGGAGAAAGAAGTAGGGGTGATACATGGTTTATAGGCAAAGCATGTTTGTTTCAGATCAAAGATTAGCGTTTCAAAGTTGTGGAAAAGTGACCATGCAACAATATGCAACACATTCGGATTATCTGATAAGTTTCAAAGCTACTAAGTAAGCCCGTTTCAAGTCTCCAGACCGACATCTGCCATCCAGTGATTTTCTTAGTCCTGAAAAATACGATGTGTAAACATAAACCACAAAGATCGGCCTCCGAGGTTGAACCCTTACGAAAGAGACATCTGGTAGCGCCAATGCCAAAAAAAAATCACACCAGAAGGACAATTCCCTTCCCCCCCAGCCCATTAAAGCTTACCATTTCCTATTCCAATACGTTCCATAGAGGGCATCGCTCGGCTCATTTTCGCGTGGGTCATACTAGAGCGGCTAGCTAGTCGGCTGTTTGAGCTCTCTAATCGAGGGGTAAGGATGTCTAATATGTCATAATGGCTCACTATATAAAGAACCCGCTTGCTCAACCTTCGACTCCTTTCCCGATCCTTTGCTTGTTGCTTCTTCTTTTATAACAGGAAACAAAGGAATTTATACACTTTAA SEQ ID NO: 65AAATTAATCCATAAGATAAGGCAAATGTGCTTAAGTAATTGAAAACAGTGTTGTGATTATATAAGCATGGTATTTGAATAGAACTACTGGGGTTAACTTATCTAGTAGGATGGAAGTTGAGGGAGATCAAGATGCTTAAAGAAAAGGATTGGCCAATATGAAAGCCATAATTAGCAATACTTATTTAATCAGATAATTGTGGGGCATTGTGACTTGACTTTTACCAGGACTTCAAACCTCAACCATTTAAACAGTTATAGAAGACGTACCGTCACTTTTGCTTTTAATGTGATCTAAATGTGATCACATGAACTCAAACTAAAATGATATCTTTTACTGGACAAAAATGTTATCCTGCAAACAGAAAGCTTTCTTCTATTCTAAGAAGAACATTTACATTGGTGGGAAACCTGAAAACAGAAAATAAATACTCCCCAGTGACCCTATGAGCAGGATTTTTGCATCCCTATTGTAGGCCTTTCAAACTCACACCTAATATTTCCCGCCACTCACACTATCAATGATCACTTCCCAGTTCTCTTCTTCCCCTATTCGTACCATGCAACCCTTACACGCCTTTTCCATTTCGGTTCGGATGCGACTTCCAGTCTGTGGGGTACGTAGCCTATTCTCTTAGCCGGTATTTAAACATACAAATTCACCCAAATTCTACCTTGATAAGGTAATTGATTAATTTCATAAAT SEQ ID NO: 66TCCAAACCAAACGGTCTAGCAAAAACGATAACTTTAAAGAACTTTTCAATTGGTTTTGTACACTACCACCGGTTTACTACCTCTGCCTTCGGTTCTTCTCCTCACATTTTTCGCAACTGGGATAGCGTAGCCTAAAGTGTCACATGCTCGCTGCTCACATTCCCTACACAACAGAGATTGTCAGCAGAGGAAATTGAGCTCCACCATTCAACACTTGTGGATTTATGATAGTCTGTGCTATCAGCTCTCTTTTTTTTGTTGCTGTAGAATTTACCGTGCTAGCAACCTTTTAAACTTTGTTTAGCTCTCCTTCCCTCTTCCATTCATCTGTTTCGGTCCGATCCGTCTCTGGTCATCTCCTCCGCATTTTTTTTTTACCGTTAGCGATAGGGGTCAGATCAATTCAATCAGTTTTGGCAAGGGTATTTAAAGGTGGCGAAATCCCCCTCCGTTTGTTGAACACATCCAACTATTCTCAACCCAACCATCTAACTAATCGTA SEQ ID NO: 67CGCAGCGTTTTCTGACGGTACTAGAGGACTCTTAGGGGAAGGTAGAATCAATAAAGATCATATTAGGTAAGCAAATTTTGGATGGAATAGGAGACTAGGTGTGGATGCGCGATCTCGCCAAATTGCACGACCAGAGTGGATGCCGGATGGTGGTAAACCGTTTCTTCCTTTTTACCACCCAAGTGCGAGTGAAACACCCCATGGCTGCTCTCCGATTGCCCCTCTACAGGCATAAGGGTGTGACTTTGTGGGCTTGAATTTTACACCCCCTCCAACTTTTCTCGCATCAATTGATCCTGTTACCAATATTGCATGCCCGGAGGAGACTTGCCCCCTAATTTCGCGGCGTCGTCCCGGATCGCAGGGTGAGACTGTAGAGACCCCACATAGTGACAATGATTATGTAAGAAGAGGGGGGTGATTCGGCCGGCTATCGAACTCTAACAACTAGGGGGGTGAACAATGCCCAGCAGTCCTCCCCACTCTTTGACAAATCAGTATCACCGATTAACACCCCAAATCTTATTCTCAACGGTCCCTCATCCTTGCACCCCTCTTTGGACAAATGGCAGTTAGCATTGGTGCACTGACTGACTGCCCAACCTTAAACCCAAATTTCTTAGAAGGGGCCCATCTAGTTAGCGAGGGGTGAAAAATTCCTCCATCGGAGATGTATTGACCGTAAGTTGCTGCTTAAAAAAAATCAGTTCAGATAGCGAGACTTTTTTGATTTCGCAACGGGAGTGCCTGTTCCATTCGATTGCAATTCTCACCCCTTCTGCCCAGTCCTGCCAATTGCCCATGAATCTGCTAATTTCGTTGATTCCCACCCCCCTTTCCAACTCCACAAATTGTCCAATCTCGTTTTCCATTTGGGAGAATCTGCATGTCGACTACATAAAGCGACCGGTGTCCGAAAAGATCTGTGTAGTTTTCAACATTTTGTGCTCCCCCCGCTGTTTGAAAACGGGGGTGAGCGCTCTCCGGGGTGCGAATTCGTGCCCAATTCCTTTCACCCTGCCTATTGTAGACGTCAACCCGCATCTGGTGCGAATATAGCGCACCCCCAATGATCACACCAACAATTGGTCCACCCCTCCCCAATCTCTAATATTCACAATTCACCTCACTATAAATACCCCTGTCCTGCTCCCAAATTCTTTTTTCCTTCTTCCATCAGCTACTAGCTTTTATCTTATTTACTTTACGAAA SEQ ID NO: 68TGTGTCTGTAAATTTAAATCCAAAGAAAAATAAAGGGCACTACATAGAACAACACAATCAACCTACATAGCTCTCTTTTTTTTTTTTTTTTTTTTTTTCTTTTTTGTTTTTTCTCAATTTTCTTCATTTTTTGCATTGTTACTACTCTCCCATTAAGGGAAATTCTACCAGGAAAACCGAAGAAGACAAATGCAAAAGGGAAATATGAATACGCATGTATGCGCGCAAAACCGCACTTACAGAGGGCATTAGGACATT SEQ ID NO: 69AGATCTAACATCCAAAGACGAAAGGTTGAATGAAACCTTTTTGCCATCCGACATCCACAGGTCCATTCTCACACATAAGTGCCAAACGCAACAGGAGGGGATACACTAGCAGCAGACCGTTGCAAACGCAGGACCTCCACTCCTCTTCTCCTCAACACCCACTTTTGCCATCGAAAAACCAGCCCAGTTATTGGGCTTGATTGGAGCTCGCTCATTCCAATTCCTTCTATTAGGCTACTAACACCATGACTTTATTAGCCTGTCTATCCTGGCCCCCCTGGCGAGGTTCATGTTTGTTTATTTCCGAATGCAACAAGCTCCGCATTACACCCGAACATCACTCCAGATGAGGGCTTTCTGAGTGTGGGGTCAAATAGTTTCATGTTCCCCAAATGGCCCAAAACTGACAGTTTAAACGCTGTCTTGGAACCTAATATGACAAAAGCGTGATCTCATCCAAGATGAACTAAGTTTGGTTCGTTGAAATGCTAACGGCCAGTTGGTCAAAAAGAAACTTCCAAAAGTCGGCATACCGTTTGTCTTGTTTGGTATTGATTGACGAATGCTCAAAAATAATCTCATTAATGCTTAGCGCAGTCTCTCTATCGCTTCTGAACCCCGGTGCACCTGTGCCGAAACGCAAATGGGGAAACACCCGCTTTTTGGATGATTATGCATTGTCTCCACATTGTATGCTTCCAAGATTCTGGTGGGAATACTGCTGATAGCCTAACGTTCATGATCAAAATTTAACTGTTCTAACCCCTACTTGACAGCAATATATAAACAGAAGGAAGCTGCCCTGTCTTAAACCTTTTTTTTTATCATCATTATTAGCTTACTTTCATAATTGCGACTGGTTCCAATTGACAAGCTTTTGATTTTAACGACTTTTAACGACAACTTGAGAAGATCAAAAAACAACTAATTATTCGAAACGGAATTCGCTGGATCCTACGTAGAATTCCCTAGGGCGGCCGCGAATTAATTCGCCTTAGACATGACTGTTCCTCAGTTCAAGTTGGGCACTTACGAGAAGACCGGTCTTGCTAGATTCTAATCAAGAGGATGTCAGAATGCCATTTGCCTGAGAGATGCAGGCTTCATTTTTGATACTTTTTTATTTGTAACCTATATAGTATAGGATTTTTTTTGTCATTTTGTTTCTTCTCGTACGAGCTTGCTCCTGATCAGCCTATCTCGCAGCTGATGAATATCTTGTGGTAGGGGTTTGGGAAAATCATTCGAGTTTGATGTTTTTCTTGGTATTTCCCACTCCTCTTCAGAGTACAGAAGATTAAGTGAGAAGTTCGTTTGTGCAAGCTTATCGATAAGCTTTAATGCGGTAGTTTATCACAGTTAAATTGCTAACGCAGTCAGGCACCGTGTATGAAATCTAACAATGCGCTCATCGTCATCCTCGGCACCGTCACCCTGGATGCTGTAGGCATAGGCTTGGTTATGCCGGTACTGCCGGGCCTCTTGCGGGATATCGTCCATTCCGACAGCATCGCCAGTCACTATGGCGTGCTGCTAGCGCTATATGCGTTGATGCAATTTCTATGCGCACCCGTTCTCGGAGCACTGTCCGACCGCTTTGGCCGCCGCCCAGTCCTGCTCGCTTCGCTACTTGGAGCCACTATCGACTACGCGATCATGGCGACCACACCCGTCCTGTGGATCTATCGAATCTAAATGTAAGTTAAAATCTCTAAATAATTAAATAAGTCCCAGTTTCTCCATACGAACCTTAACAGCATTGCGGTGAGCATCTAGACCTTCAACAGCAGCCAGATCCATCACTGCTTGGCCAATATGTTTCAGTCCCTCAGGAGTTACGTCTTGTGAAGTGATGAACTTCTGGAAGGTTGCAGTGTTAACTCCGCTGTATTGACGGGCATATCCGTACGTTGGCAAAGTGTGGTTGGTACCGGAGGAGTAATCTCCACAACTCTCTGGAGAGTAGGCACCAACAAACACAGATCCAGCGTGTTGTACTTGATCAACATAAGAAGAAGCATTCTCGATTTGCAGGATCAAGTGTTCAGGAGCGTACTGATTGGACATTTCCAAAGCCTGCTCGTAGGTTGCAACCGATAGGGTTGTAGAGTGTGCAATACACTTGCGTACAATTTCAACCCTTGGCAACTGCACAGCTTGGTTGTGAACAGCATCTTCAATTCTGGCAAGCTCCTTGTCTGTCATATCGACAGCCAACAGAATCACCTGGGAATCAATACCATGTTCAGCTTGAGACAGAAGGTCTGAGGCAACGAAATCTGGATCAGCGTATTTATCAGCAATAACTAGAACTTCAGAAGGCCCAGCAGGCATGTCAATACTACACAGGGCTGATGTGTCATTTTGAACCATCATCTTGGCAGCAGTAACGAACTGGTTTCCTGGACCAAATATTTTGTCACACTTAGGAACAGTTTCTGTTCCGTAAGCCATAGCAGCTACTGCCTGGGCGCCTCCTGCTAGCACGATACACTTAGCACCAACCTTGTGGGCAACGTAGATGACTTCTGGGGTAAGGGTACCATCCTTCTTAGGTGGAGATGCAAAAACAATTTCTTTGCAACCAGCAACTTTGGCAGGAACACCCAGCATCAGGGAAGTGGAAGGCAGAATTGCGGTTCCACCAGGAATATAGAGGCCAACTTTCTCAATAGGTCTTGCAAAACGAGAGCAGACTACACCAGGGCAAGTCTCAACTTGCAACGTCTCCGTTAGTTGAGCTTCATGGAATTTCCTGACGTTATCTATAGAGAGATCAATGGCTCTCTTAACGTTATCTGGCAATTGCATAAGTTCCTCTGGGAAAGGAGCTTCTAACACAGGTGTCTTCAAAGCGACTCCATCAAACTTGGCAGTTAGTTCTAAAAGGGCTTTGTCACCATTTTGACGAACATTGTCGACAATTGGTTTGACTAATTCCATAATCTGTTCCGTTTTCTGGATAGGACGACGAAGGGCATCTTCAATTTCTTGTGAGGAGGCCTTAGAAACGTCAATTTTGCACAATTCAATACGACCTTCAGAAGGGACTTCTTTAGGTTTGGATTCTTCTTTAGGTTGTTCCTTGGTGTATCCTGGCTTGGCATCTCCTTTCCTTCTAGTGACCTTTAGGGACTTCATATCCAGGTTTCTCTCCACCTCGTCCAACGTCACACCGTACTTGGCACATCTAACTAATGCAAAATAAAATAAGTCAGCACATTCCCAGGCTATATCTTCCTTGGATTTAGCTTCTGCAAGTTCATCAGCTTCCTCCCTAATTTTAGCGTTCAACAAAACTTCGTCGTCAAATAACCGTTTGGTATAAGAACCTTCTGGAGCATTGCTCTTACGATCCCACAAGGTGGCTTCCATGGCTCTAAGACCCTTTGATTGGCCAAAACAGGAAGTGCGTTCCAAGTGACAGAAACCAACACCTGTTTGTTCAACCACAAATTTCAAGCAGTCTCCATCACAATCCAATTCGATACCCAGCAACTTTTGAGTTGCTCCAGATGTAGCACCTTTATACCACAAACCGTGACGACGAGATTGGTAGACTCCAGTTTGTGTCCTTATAGCCTCCGGAATAGACTTTTTGGACGAGTACACCAGGCCCAACGAGTAATTAGAAGAGTCAGCCACCAAAGTAGTGAATAGACCATCGGGGCGGTCAGTAGTCAAAGACGCCAACAAAATTTCACTGACAGGGAACTTTTTGACATCTTCAGAAAGTTCGTATTCAGTAGTCAATTGCCGAGCATCAATAATGGGGATTATACCAGAAGCAACAGTGGAAGTCACATCTACCAACTTTGCGGTCTCAGAAAAAGCATAAACAGTTCTACTACCGCCATTAGTGAAACTTTTCAAATCGCCCAGTGGAGAAGAAAAAGGCACAGCGATACTAGCATTAGCGGGCAAGGATGCAACTTTATCAACCAGGGTCCTATAGATAACCCTAGCGCCTGGGATCATCCTTTGGACAACTCTTTCTGCCAAATCTAGGTCCAAAATCACTTCATTGATACCATTATTGTACAACTTGAGCAAGTTGTCGATCAGCTCCTCAAATTGGTCCTCTGTAACGGATGACTCAACTTGCACATTAACTTGAAGCTCAGTCGATTGAGTGAACTTGATCAGGTTGTGCAGCTGGTCAGCAGCATAGGGAAACACGGCTTTTCCTACCAAACTCAAGGAATTATCAAACTCTGCAACACTTGCGTATGCAGGTAGCAAGGGAAATGTCATACTTGAAGTCGGACAGTGAGTGTAGTCTTGAGAAATTCTGAAGCCGTATTTTTATTATCAGTGAGTCAGTCATCAGGAGATCCTCTACGCCGGACGCATCGTGGCCGACCTGCAGGGGGGGGGGGGGCGCTGAGGTCTGCCTCGTGAAGAAGGTGTTGCTGACTCATACCAGGCCTGAATCGCCCCATCATCCAGCCAGAAAGTGAGGGAGCCACGGTTGATGAGAGCTTTGTTGTAGGTGGACCAGTTGGTGATTTTGAACTTTTGCTTTGCCACGGAACGGTCTGCGTTGTCGGGAAGATGCGTGATCTGATCCTTCAACTCAGCAAAAGTTCGATTTATTCAACAAAGCCGCCGTCCCGTCAAGTCAGCGTAATGCTCTGCCAGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATCAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGCGATTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCAAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACCGTTATTCATTCGTGATTGCGCCTGAGCGAGACGAAATACGCGATCGCTGTTAAAAGGACAATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTGAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATCGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTCGAGCAAGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTTTTATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAACGTGGCTTTCCCCCCCCCCCCTGCAGGTCGGCATCACCGGCGCCACAGGTGCGGTTGCTGGCGCCTATATCGCCGACATCACCGATGGGGAAGATCGGGCTCGCCACTTCGGGCTCATGAGCGCTTGTTTCGGCGTGGGTATGGTGGCAGGCCCCGTGGCCGGGGGACTGTTGGGCGCCATCTCCTTGCATGCACCATTCCTTGCGGCGGCGGTGCTCAACGGCCTCAACCTACTACTGGGCTGCTTCCTAATGCAGGAGTCGCATAAGGGAGAGCGTCGAGTATCTATGATTGGAAGTATGGGAATGGTGATACCCGCATTCTTCAGTGTCTTGAGGTCTCCTATCAGATTATGCCCAACTAAAGCAACCGGAGGAGGAGATTTCATGGTAAATTTCTCTGACTTTTGGTCATCAGTAGACTCGAACTGTGAGACTATCTCGGTTATGACAGCAGAAATGTCCTTCTTGGAGACAGTAAATGAAGTCCCACCAATAAAGAAATCCTTGTTATCAGGAACAAACTTCTTGTTTCGAACTTTTTCGGTGCCTTGAACTATAAAATGTAGAGTGGATATGTCGGGTAGGAATGGAGCGGGCAAATGCTTACCTTCTGGACCTTCAAGAGGTATGTAGGGTTTGTAGATACTGATGCCAACTTCAGTGACAACGTTGCTATTTCGTTCAAACCATTCCGAATCCAGAGAAATCAAAGTTGTTTGTCTACTATTGATCCAAGCCAGTGCGGTCTTGAAACTGACAATAGTGTGCTCGTGTTTTGAGGTCATCTTTGTATGAATAAATCTAGTCTTTGATCTAAATAATCTTGACGAGCCAAGGCGATAAATACCCAAATCTAAAACTCTTTTAAAACGTTAAAAGGACAAGTATGTCTGCCTGTATTAAACCCCAAATCAGCTCGTAGTCTGATCCTCATCAACTTGAGGGGCACTATCTTGTTTTAGAGAAATTTGCGGAGATGCGATATCGAGAAAAAGGTACGCTGATTTTAAACGTGAAATTTATCTCAAGATCTCTGCCTCGCGCGTTTCGGTGATGACGGTGAAAACCTCTGACACATGCAGCTCCCGGAGACGGTCACAGCTTGTCTGTAAGCGGATGCCGGGAGCAGACAAGCCCGTCAGGGCGCGTCAGCGGGTGTTGGCGGGTGTCGGGGCGCAGCCATGACCCAGTCACGTAGCGATAGCGGAGTGTATACTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCAATGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTGCAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAACACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCTAAGAAACCATTATTATCATGACATTAACCTATAAAAATAGGCGTATCACGAGGCCCTTTCGTCTTCAAGAATTAATTCTCATGTTTGACAGCTTATCATCGATAAGCTGACTCATGTTGGTATTGTGAAATAGACGCAGATCGGGAACACTGAAAAATAACAGTTATTATTCG SEQ ID NO: 70AGATCTAACATCCAAAGACGAAAGGTTGAATGAAACCTTTTTGCCATCCGACATCCACAGGTCCATTCTCACACATAAGTGCCAAACGCAACAGGAGGGGATACACTAGCAGCAGACCGTTGCAAACGCAGGACCTCCACTCCTCTTCTCCTCAACACCCACTTTTGCCATCGAAAAACCAGCCCAGTTATTGGGCTTGATTGGAGCTCGCTCATTCCAATTCCTTCTATTAGGCTACTAACACCATGACTTTATTAGCCTGTCTATCCTGGCCCCCCTGGCGAGGTTCATGTTTGTTTATTTCCGAATGCAACAAGCTCCGCATTACACCCGAACATCACTCCAGATGAGGGCTTTCTGAGTGTGGGGTCAAATAGTTTCATGTTCCCCAAATGGCCCAAAACTGACAGTTTAAACGCTGTCTTGGAACCTAATATGACAAAAGCGTGATCTCATCCAAGATGAACTAAGTTTGGTTCGTTGAAATGCTAACGGCCAGTTGGTCAAAAAGAAACTTCCAAAAGTCGGCATACCGTTTGTCTTGTTTGGTATTGATTGACGAATGCTCAAAAATAATCTCATTAATGCTTAGCGCAGTCTCTCTATCGCTTCTGAACCCCGGTGCACCTGTGCCGAAACGCAAATGGGGAAACACCCGCTTTTTGGATGATTATGCATTGTCTCCACATTGTATGCTTCCAAGATTCTGGTGGGAATACTGCTGATAGCCTAACGTTCATGATCAAAATTTAACTGTTCTAACCCCTACTTGACAGCAATATATAAACAGAAGGAAGCTGCCCTGTCTTAAACCTTTTTTTTTATCATCATTATTAGCTTACTTTCATAATTGCGACTGGTTCCAATTGACAAGCTTTTGATTTTAACGACTTTTAACGACAACTTGAGAAGATCAAAAAACAACTAATTATTCGAAGgatctgaattcataGCTAGCTTGGAGAAGAGGcCttaattaactgGGCCGCGAATTAATTCGCCTTAGACATGACTGTTCCTCAGTTCAAGTTGGGCACTTACGAGAAGACCGGTCTTGCTAGATTCTAATCAAGAGGATGTCAGAATGCCATTTGCCTGAGAGATGCAGGCTTCATTTTTGATACTTTTTTATTTGTAACCTATATAGTATAGGATTTTTTTTGTCATTTTGTTTCTTCTCGTACGAGCTTGCTCCTGATCAGCCTATCTCGCAGCTGATGAATATCTTGTGGTAGGGGTTTGGGAAAATCATTCGAGTTTGATGTTTTTCTTGGTATTTCCCACTCCTCTTCAGAGTACAGAAGATTAAGTGAGACGTTCGTTTGTGCAAGCTTATCGATAAGCTTTAATGCGGTAGTTTATCACAGTTAAATTGCTAACGCAGTCAGGCACCGTGTATGAAATCTAACAATGCGCTCATCGTCATCCTCGGCACCGTCACCCTGGATGCTGTAGGCATAGGCTTGGTTATGCCGGTACTGCCGGGCCTCTTGCGGGATATCGTCCATTCCGACAGCATCGCCAGTCACTATGGCGTGCTGCTAGGTACAACTTGAGCAAGTTGTCGATCAGCTCCTCAAATTGGTCCTCTGTAACGGATGACTCAACTTGCACATTAACTTGAAGCTCAGTCGATTGAGTGAACTTGATCAGGTTGTGCAGCTGGTCAGCAGCATAGGGAAACACGGCTTTTCCTACCAAACTCAAGGAATTATCAAACTCTGCAACACTTGCGTATGCAGGTAGCAAGGGAAATGTCATACTTGAAGTCGGACAGTGAGTGTAGTCTTGAGAAATTCTGAAGCCGTATTTTTATTATCAGTGAGTCAGTCATCAGGAGATCCTCTACGCCGGACGCATCGTGGCCGACCTGCAGGGGGGGGGGGGGCGCTGAGGTCTGCCTCGTGAAGAAGGTGTTGCTGACTCATACCAGCTGAATCGCCCCATCATCCAGCCAGAAAGTGAGGGAGCCACGGTTGATGAGAGCTTTGTTGTAGGTGGACCAGTTGGTGATTTTGAACTTTTGCTTTGCCACGGAACGGTCTGCGTTGTCGGGAAGATGCGTGATCTGATCCTTCAACTCAGCAAAAGTTCGATTTATTCAACAAAGCCGCCGTCCCGTCAAGTCAGCGTAATGCTCTGCCAGTGTTACAACCAATTAACCAATTCTGATTAGAAAAACTCATCGAGCATCAAATGAAACTGCAATTTATTCATATCAGGATTATCAATACCATATTTTTGAAAAAGCCGTTTCTGTAATGAAGGAGAAAACTCACCGAGGCAGTTCCATAGGATGGCAAGATCCTGGTATCGGTCTGCGATTCCGACTCGTCCAACATCAATACAACCTATTAATTTCCCCTCGTCAAAAATAAGGTTATCAAGTGAGAAATCACCATGAGTGACGACTGAATCCGGTGAGAATGGCAAAAGCTTATGCATTTCTTTCCAGACTTGTTCAACAGGCCAGCCATTACGCTCGTCATCAAAATCACTCGCATCAACCAAACCGTTATTCATTCGTGATTGCGCCTGAGCGAGACGAAATACGCGATCGCTGTTAAAAGGACAATTACAAACAGGAATCGAATGCAACCGGCGCAGGAACACTGCCAGCGCATCAACAATATTTTCACCTGAATCAGGATATTCTTCTAATACCTGGAATGCTGTTTTCCCGGGGATCGCAGTGGTGAGTAACCATGCATCATCAGGAGTACGGATAAAATGCTTGATGGTCGGAAGAGGCATAAATTCCGTCAGCCAGTTTAGTCTGACCATCTCATCTGTAACATCATTGGCAACGCTACCTTTGCCATGTTTCAGAAACAACTCTGGCGCATCGGGCTTCCCATACAATCGATAGATTGTCGCACCTGATTGCCCGACATTATCGCGAGCCCATTTATACCCATATAAATCAGCATCCATGTTGGAATTTAATCGCGGCCTCGAGCAAGACGTTTCCCGTTGAATATGGCTCATAACACCCCTTGTATTACTGTTTATGTAAGCAGACAGTTTTATTGTTCATGATGATATATTTTTATCTTGTGCAATGTAACATCAGAGATTTTGAGACACAACGTGGCTTTCCCCCCCCCCCCTGCAGGTCGGCATCACCGGCGCCACAGGTGCGGTTGCTGGCGCCTATATCGCCGACATCACCGATGGGGAAGATCGGGCTCGCCACTTCGGGCTCATGAGCGCTTGTTTCGGCGTGGGTATGGTGGCAGGCCCCGTGGCCGGGGGACTGTTGGGCGCCATCTCCTTGCATGCACCATTCCTTGCGGCGGCGGTGCTCAACGGCCTCAACCTACTACTGGGCTGCTTCCTAATGCAGGAGTCGCATAAGGGAGAGCGTCGAGTATCTATGATTGGAAGTATGGGAATGGTGATACCCGCATTCTTCAGTGTCTTGAGGTCTCCTATCAGATTATGCCCAACTAAAGCAACCGGAGGAGGAGATTTCATGGTAAATTTCTCTGACTTTTGGTCATCAGTAGACTCGAACTGTGAGACTATCTCGGTTATGACAGCAGAAATGTCCTTCTTGGAGACAGTAAATGAAGTCCCACCAATAAAGAAATCCTTGTTATCAGGAACAAACTTCTTGTTTCGAACTTTTTCGGTGCCTTGAACTATAAAATGTAGAGTGGATATGTCGGGTAGGAATGGAGCGGGCAAATGCTTACCTTCTGGACCTTCAAGAGGTATGTAGGGTTTGTAGATACTGATGCCAACTTCAGTGACAACGTTGCTATTTCGTTCAAACCATTCCGAATCCAGAGAAATCAAAGTTGTTTGTCTACTATTGATCCAAGCCAGTGCGGTCTTGAAACTGACAATAGTGTGCTCGTGTTTTGAGGTCATCTTTGTATGAATAAATCTAGTCTTTGATCTAAATAATCTTGACGAGCCAAGGCGATAAATACCCAAATCTAAAACTCTTTTAAAACGTTAAAAGGACAAGTATGTCTGCCTGTATTAAACCCCAAATCAGCTCGTAGTCTGATCCTCATCAACTTGAGGGGCACTATCTTGTTTTAGAGAAATTTGCGGAGATGCGATATCGAGAAAAAGGTACGCTGATTTTAAACGTGAAATTTATCTCAAGATCTCTGCCTCGCGCGTTTCGGTGATGACGGTGAAAACCTCTGACACATGCAGCTCCCGGAGACGGTCACAGCTTGTCTGTAAGCGGATGCCGGGAGCAGACAAGCCCGTCAGGGCGCGTCAGCGGGTGTTGGCGGGTGTCGGGGCGCAGCCATGACCCAGTCACGTAGCGATAGCGGAGTGTATACTGGCTTAACTATGCGGCATCAGAGCAGATTGTACTGAGAGTGCACCATATGCGGTGTGAAATACCGCACAGATGCGTAAGGAGAAAATACCGCATCAGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCAATGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGGACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTGCAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAACACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCTAAGAAACCATTATTATCATGACATTAACCTATAAAAATAGGCGTATCACGAGGCCCTTTCGTCTTCAAGAATTAATTCTCATGTTTGACAGCTTATCATCGATAAGCTGACTCATGTTGGTATTGTGAAATAGACGCAGATCGGGAACACTGAAAAATAACAGTTATTATTCGSEQ ID NO: 71NPRENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVCAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 72NPRENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 73NPRENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVCAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSQNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 74NPRENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFISDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVCAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSQNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 75NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 76NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVESGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFSGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGGESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 77NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVESGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFSGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGGESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVKILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 78NARENFLKCFSKHIPNNVANPKLVYTQHDQLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 79NARENFLKCFSQHIGNRGNVYTQHDQLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 80NARENFLKCFSQHIPNANPKLVYTQHDQLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 81NARENLLKCLSQHGDGTGKTVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAKIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 82NARENLLKCLSQHDGTGKTVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAKIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 83NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 84NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYISSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 85NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDSRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 86NARENFLKCFSQHIPNDATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSFPGGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 87NARENFLKCFSQHIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNEDLSFPGGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 88NARENFLKCFSQHIPNDATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAENFGIIVAWKIRLVAVPKSTMFSVKKNMEIHALVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHVYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 89NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGGTGSGTFKKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 90NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGGTGSGTKKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 91NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGGDGTGKKEILLDRSAKGNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 92NARENFLKCFSQHIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTIFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITKNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQFSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTKVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 93NARENFLKCFSQHIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGSVLDRQSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKQPIPESVFVKILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 94NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNPTPNTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 95NAREDFLKCFSQHIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRKYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKNGAIHELVKLVNKWQNIAYKYDEDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVKILEKLYEEDIGAGMYALYPYGGIMDEKSESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 96NARENFLKCFSQHIPNNATNLKLVYTQNNPLYQSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQATILCSKKVGLQIRTRSGGHDSEGLSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKNVEIHALVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGTVYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 97NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLDSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 98NARENFLKCFSQYIPNDATNLKLVYTQNNPLYMSVLDSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 99NARENFLKCFSQYIPNDATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMQKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 100NARENFLKCFSQHIPNNATNLKLVYTQNNPLYMSVLDSTIHNLRFTSDTTPKPLVIVTPSHVSHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVESGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFSGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGGESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVKILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 101NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYICSWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNDYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 102NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAENFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 103NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGADSFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 104NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGADNFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 105NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLDSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 106NARENFLKCFSQHIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTIFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITKNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQFSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTKVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 107NARENFLKCFSQHIPNDATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSFPGGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 108NARENFLKCFSQHIPNNATNLKLVYTQNNPLYMSVLDSTIHNLRFTSDTTPKPLVIVTPSNVAHIQATILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTIFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITKNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQFSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTKVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 109NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDARQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 110NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDTRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 111NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDPRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 112NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDSRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQNGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 113NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIQNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNENKEILLDRSAGQKGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 114NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIQNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQRGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNEMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 115NARENFLKCFSQYIPNNATNLKLVYTQNNPLYMSVLNSTIHNLRFTSDTTPKPLVIVTPSHVSHIQGTILCSKKVGLQIRTRSGGHDSEGMSYISQVPFVIVDLRNMRSIKIDVHSQTAWVEAGATLGEVYYWVNEKNENLSLAAGYCPTVGAGGHFGGGGYGPLMRNYGLAADNIIDAHLVNVHGKVLDRKSMGEDLFWALRGGGAESFGIIVAWKIRLVAVPKSTMFSVKKIMEIHELVKLVNKWQNIAYKYDKDLLLMTHFITRNITDNQGKNKTAIHTYFSSVFLGGVDSLVDLMNKSFPELGIKKTDCRQLSWIDTIIFYSGVVNYDTDNFNKEILLDRSAGQRGAFKIKLDYVKKPIPESVFVQILEKLYEEDIGAGMYALYPYGGIMDEISESAIPFPHRAGILYELWYIASWEKQEDNEKHLNWIRNIYNFMTPYVSKNPRLAYLNYRDLDIGINDPKNPNNYTQARIWGEKYFGKNFDRLVKVKTLVDPNNFFRNEQSIPPLPRHRHSEQ ID NO: 116MRFPSIFTAVLFAASSALAAPVNTTTEDETAQIPAEAVIGYSDLEGDFDVAVLPFSNSTNNGLLFINTTIASIAAKEEGVSLEKREAEA SEQ ID NO: 117MQYKKTLVASALAATTLAAYAPSEPWSTLTPTATYSGGVTDYASTFGIAVQPISTTSSASSAATTASLEKREADASEQ ID NO: 118MRFPSIFTAVLFAASSALAARAYAPSEPWSTLTPTATYSGGVTDYASTFGIAVQPISTTSSASSAATTASSASLEKREADA SEQ ID NO: 119MRFPSIFTAVLFAASSALAARAYAPSEPWSTLTPTATYSGGVTDYASTFGIAVQPISTTSSASSAATTASSARAYAPSEPWSTLTPTATYSGGVTDYASTFGIAVQPISTTSSASSAATTASSASLEKREADASEQ ID NO: 120 MLLQAFLFLLAGFAAKISAGSASLEKREADA SEQ ID NO: 121MFSPILSLEIILALATLQSVFAASLEKREADA SEQ ID NO: 122MYRNLIIATALTCGAYSAYVPSEPWSTLTPDASLESALKDYSQTFGIAIKSLDADGSASLEKREADASEQ ID NO: 123 MRQVWFSWIVGLFLCFFNVSSAASLEKREADA SEQ ID NO: 124MRQVWFSWIVGLFLCFFNVSSAAPVNTTTEDETAQIPAEAVIGYSDLEGDEDVAVLPFSNSTNNGLLFINTTIASIAAKEEGASLEKREADA SEQ ID NO: 125 MFNLKTILISTLASIAVAASLEKREADASEQ ID NO: 126 YPYDVPDYA SEQ ID NO: 127 HHHHHH SEQ ID NO: 128 HNHNHNHNSEQ ID NO: 129 TATCCATATGATGTTCCAGATTATGCT

Enumerated Embodiments

The following enumerated embodiments are provided, the numbering ofwhich is not to be construed as designating levels of importance.

Embodiment 1 provides a recombinant vector comprising a promoter,secretion tag, gene of interest (GOI), and optionally a purificationand/or a detection tag, wherein the gene of interest comprises apolynucleotide sequence encoding a polypeptide with at least 90%, 95%,98%, or 99.9% sequence identity to the sequence as set forth in any oneof SEQ ID NOs: 72-115.

Embodiment 2 provides the recombinant vector of embodiment 1, whereinthe polynucleotide sequence encodes a polypeptide as set forth in anyone of SEQ ID NOs: 72-115.

Embodiment 3 provides the recombinant vector of embodiment 1, whereinthe polynucleotide sequence comprises the sequence as set forth in anyone of SEQ ID NOs: 2-45, or a sequence comprising at least 90%, 95%,98%, 99%, or 99.9% sequence identity to the sequence as set forth in anyone of SEQ ID NOs: 2-45.

Embodiment 4 provides the recombinant vector of embodiment 1, whereinthe gene of interest is operably linked to a promoter.

Embodiment 5 provides the recombinant vector of embodiment 4, whereinthe promoter is a polynucleotide as set forth in any one of SEQ ID NOs:59-68.

Embodiment 6 provides the recombinant vector of embodiment 5, whereinthe promoter has a polynucleotide sequence comprising at least 90%, 95%,98%, or 99% sequence identity to the sequence of SEQ ID NOs: 59-68.

Embodiment 7 provides the recombinant vector of embodiment 4, whereinthe promoter is a constitutive promoter or an inducible promoter.

Embodiment 8 provides the recombinant vector of embodiment 4, whereinthe promoter is selected from a group consisting of an alcohol oxidase 1promoter (pAOX1), an alcohol oxidase 2 promoter (pAOX2), adihydroxyacetone kinase promoter (pDAK), an S-hydroxymethyl-glutathionehydrolase promoter (pFGH), an NAD⁺-dependent formylglutathionedehydrogenase promoter (pFDH), a fructose 1,6-bisphosphate aldolasepromoter (pFBA2), a peroxisomal membrane signal receptor PTS1 promoter(pPEX5), a peroxisomal protein Pex8p promoter (pPEX8), an alcoholdehydrogenase 2 promoter (pADH2) and a peroxin Pex14p promoter (pPEX14).

Embodiment 9 provides the recombinant vector of embodiment 1, comprisinga secretion tag as set forth in any one of SEQ ID NOs: 46-55 and 130.

Embodiment 10 provides the recombinant vector of embodiment 9, whereinthe sequence of the secretion tag is at least 90%, 95%, 98%, 99%, or100% identical to SEQ ID NOs: 46-55 and 130.

Embodiment 11 provides the recombinant vector of embodiment 1,comprising a purification/detection tag as set forth in any one of SEQID NOs: 56-58 and 129.

Embodiment 12 provides the recombinant vector of embodiment 11, whereinthe purification/detection tag is selected from the group consisting ofa human influenza hemagglutinin (HA) tag, a His 6 tag and an HN tag.

Embodiment 13 provides a host expression system comprising therecombinant vector of embodiment 1.

Embodiment 14 provides the host expression system of embodiment 13,comprising a microbial cell, a yeast cell, a plant cell, or an animalcell.

Embodiment 15 provides the host expression system of embodiment 14,wherein the yeast cell is selected from the group consisting of Pichiapastoris, Pichia angusta, Pichia guillermordii, Pichia methanolica,Pichia inositovera, Hansenula polymorpha, Candida boidinii, and Yarrowialipolytica.

Embodiment 16 provides a method of producing a cannabinoid compound,comprising reacting a cannabinoid precursor with an enzyme that isexpressed by the host expression system of embodiment 13, wherein thecannabinoid precursor is compound of Formula I (see below): wherein R₁is H or —COOH and R₂ is a linear or branched CH₃, C₂H₅, C₃H₇, C₄H₉,C₅H₁₀, C₆H₁₃, C₇H₁₅ or C₈H₁₇ group.

Embodiment 17 provides a polypeptide comprising the amino acid sequenceof any one of SEQ ID NOs: 72-115 or an amino acid sequence comprising atleast 90%, 95%, 98%, or 99.9% sequence identity to any one of SEQ IDNOs: 72-115.

Embodiment 18 provides the polypeptide of embodiment 17, wherein thepolypeptide comprises the amino acid sequence of SEQ ID NO: 83, 86, 92,or 97 or an amino acid sequence comprising at least 90%, 95%, 98%, or99.9% sequence identity to SEQ ID NO: 83, 86, 92, or 97.

Embodiment 19 provides a nucleic acid comprising a polynucleotidesequence encoding a polypeptide comprising the amino acid sequence ofany one of SEQ ID NOs: 72-115 or an amino acid sequence comprising atleast 90%, 95%, 98%, or 99.9% sequence identity to any one of SEQ IDNOs: 72-115.

Embodiment 20 provides the nucleic acid of embodiment 19, wherein thenucleic acid comprises the polynucleotide sequence of any one of SEQ IDNOs: 2-45 or a polynucleotide sequence comprising at least 90%, 95%,98%, or 99.9% sequence identity to any one of SEQ ID NOs: 2-45.

Embodiment 21 provides the nucleic acid of embodiment 20, wherein thenucleic acid comprises the polynucleotide sequence of SEQ ID NO: 13, 16,22, or 27 or a polynucleotide sequence comprising at least 90%, 95%,98%, or 99.9% sequence identity to SEQ ID NO: 13, 16, 22, or 27.

OTHER EMBODIMENTS

The disclosures of each and every patent, patent application, andpublication cited herein are hereby incorporated herein by reference intheir entirety. While this invention has been disclosed with referenceto specific embodiments, it is apparent that other embodiments andvariations of this invention may be devised by others skilled in the artwithout departing from the true spirit and scope of the invention. Theappended claims are intended to be construed to include all suchembodiments and equivalent variations.

We claim:
 1. A recombinant vector comprising a promoter, secretion tag,gene of interest (GOI), and optionally a purification and/or a detectiontag, wherein the gene of interest comprises a polynucleotide sequenceencoding a polypeptide with at least 90%, 95%, 98%, or 99.9% sequenceidentity to the sequence as set forth in any one of SEQ ID NOs: 72-115.2. The recombinant vector of claim 1, wherein the polynucleotidesequence encodes a polypeptide as set forth in any one of SEQ ID NOs:72-115.
 3. The recombinant vector of claim 1, wherein the polynucleotidesequence comprises the sequence as set forth in any one of SEQ ID NOs:2-45, or a sequence comprising at least 90%, 95%, 98%, 99%, or 99.9%sequence identity to the sequence as set forth in any one of SEQ ID NOs:2-45.
 4. The recombinant vector of claim 1, wherein the gene of interestis operably linked to a promoter.
 5. The recombinant vector of claim 4,wherein the promoter is a polynucleotide as set forth in any one of SEQID NOs: 59-68.
 6. The recombinant vector of claim 5, wherein thepromoter has a polynucleotide sequence comprising at least 90%, 95%,98%, or 99% sequence identity to the sequence of SEQ ID NOs: 59-68. 7.The recombinant vector of claim 4, wherein the promoter is aconstitutive promoter or an inducible promoter.
 8. The recombinantvector of claim 4, wherein the promoter is selected from a groupconsisting of an alcohol oxidase 1 promoter (pAOX1), an alcohol oxidase2 promoter (pAOX2), a dihydroxyacetone kinase promoter (pDAK), anS-hydroxymethyl-glutathione hydrolase promoter (pFGH), an NAD-dependentformylglutathione dehydrogenase promoter (pFDH), a fructose1,6-bisphosphate aldolase promoter (pFBA2), a peroxisomal membranesignal receptor PTS1 promoter (pPEX5), a peroxisomal protein Pex8ppromoter (pPEX8), an alcohol dehydrogenase 2 promoter (pADH2) and aperoxin Pex14p promoter (pPEX14).
 9. The recombinant vector of claim 1,comprising a secretion tag as set forth in any one of SEQ ID NOs: 46-55and
 130. 10. The recombinant vector of claim 9, wherein the sequence ofthe secretion tag is at least 90%, 95%, 98%, 99%, or 100% identical toSEQ ID NOs: 46-55 and
 130. 11. The recombinant vector of claim 1,comprising a purification/detection tag as set forth in any one of SEQID NOs: 56-58 and
 129. 12. The recombinant vector of claim 11, whereinthe purification/detection tag is selected from the group consisting ofa human influenza hemagglutinin (HA) tag, a His 6 tag and an HN tag. 13.A host expression system comprising the recombinant vector of claim 1.14. The host expression system of claim 13, comprising a microbial cell,a yeast cell, a plant cell, or an animal cell.
 15. The host expressionsystem of claim 14, wherein the yeast cell is selected from the groupconsisting of Pichia pastoris, Pichia angusta, Pichia guillermordii,Pichia methanolica, Pichia inositovera, Hansenula polymorpha, Candidaboidinii, and Yarrowia lipolytica.
 16. A method of producing acannabinoid compound, comprising reacting a cannabinoid precursor withan enzyme that is expressed by the host expression system of claim 13,wherein the cannabinoid precursor is compound of Formula I (see below):wherein R₁ is H or —COOH and R₂ is a linear or branched CH₃, C₂H₅, C₃H₇,C₄H₉, C₅H₁₀, C₆H₁₃, C₇H₁₅ or C₈H₁₇ group.


17. A polypeptide comprising the amino acid sequence of any one of SEQID NOs: 72-115 or an amino acid sequence comprising at least 90%, 95%,98%, or 99.9% sequence identity to any one of SEQ ID NOs: 72-115. 18.The polypeptide of claim 17, wherein the polypeptide comprises the aminoacid sequence of SEQ ID NO: 83, 86, 92, or 97 or an amino acid sequencecomprising at least 90%, 95%, 98%, or 99.9% sequence identity to SEQ IDNO: 83, 86, 92, or
 97. 19. A nucleic acid comprising a polynucleotidesequence encoding a polypeptide comprising the amino acid sequence ofany one of SEQ ID NOs: 72-115 or an amino acid sequence comprising atleast 90%, 95%, 98%, or 99.9% sequence identity to any one of SEQ IDNOs: 72-115.
 20. The nucleic acid of claim 19, wherein the nucleic acidcomprises the polynucleotide sequence of any one of SEQ ID NOs: 2-45 ora polynucleotide sequence comprising at least 90%, 95%, 98%, or 99.9%sequence identity to any one of SEQ ID NOs: 2-45.
 21. The nucleic acidof claim 20, wherein the nucleic acid comprises the polynucleotidesequence of SEQ ID NO: 13, 16, 22, or 27 or a polynucleotide sequencecomprising at least 90%, 95%, 98%, or 99.9% sequence identity to SEQ IDNO: 13, 16, 22, or 27.